ReviewStem cells international2020
The Application of Mechanical Stimulations in Tendon Tissue Engineering.
Review in Stem cells international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Surgical treatment versus conservative management for acute Achilles tendon rupture: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2025Pooled it
- Design and Validation of a Multi-Modal Bioreactor System: Assessing the Effects of Perfusion and Cyclic Tensile Stimulation on Mechanical and Biological Properties of 3D-Printed Missing-Rib Auxetic Scaffolds.Bioengineering (Basel, Switzerland) · 2026Article
- Cyclic mechanical stimulation of TDCs improves tendon tissue maturationFrontiers in bioengineering and biotechnology · 2026Article
- Humanoid Robotic Loading Enhances Mechanotransduction in Tendon Tissue Engineering.Cyborg and bionic systems (Washington, D.C.) · 2026Article
- Cell biomechanics on muscle atrophy: from intricate mechanisms to therapeutic frontiers.Annals of medicine · 2025Review
- Suspended Tissue Engineering with Assemblable Microfluidics (STEAM).bioRxiv : the preprint server for biology · 2025Article
- Engineering ligament tissues: Synergistic power of aligned nanofibers and cyclic stretch.World journal of stem cells · 2025Article
- Electromagnetic Transduction Therapy (EMTT) Enhances Tenocyte Regenerative Potential: Evidence for Senolytic-like Effects and Matrix Remodeling.International journal of molecular sciences · 2025Article
- Historical evolution, hotspots, and trends in tendon tissue engineering: A bibliometric analysis.Regenerative therapy · 2025Article
- Magnetic scaffolds for the mechanotransduction stimulation in tendon tissue regeneration.Materials today. Bio · 2025Article
- Review
- Tendon mechanobiology in the context of tendon biofabrication.Frontiers in bioengineering and biotechnology · 2025Review
- Long Duration Continuous Ultrasound with Diclofenac Sodium Enhances Recovery from Sprains and Strains.International journal on physical medication & rehabilitation · 2025Article
- Mechanical Loading Modulates AMPK and mTOR Signaling in Muscle Cells.Journal of proteome research · 2024Article
- The development, use, and challenges of electromechanical tissue stimulation systems.Artificial organs · 2024Review
- Treatment of Tendon Injuries in the Servicemember Population across the Spectrum of Pathology: From Exosomes to Bioinductive Scaffolds.Bioengineering (Basel, Switzerland) · 2024Review
- Cell Sheet Technology: An Emerging Approach for Tendon and Ligament Tissue Engineering.Annals of biomedical engineering · 2024Review
- Equine tendon mechanical behaviour: Prospects for repair and regeneration applications.Veterinary medicine and science · 2023Review
- Bioactive Nanostructured Scaffold-Based Approach for Tendon and Ligament Tissue Engineering.Nanomaterials (Basel, Switzerland) · 2023Review
- Sonomechanobiology: Vibrational stimulation of cells and its therapeutic implications.Biophysics reviews · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tendon injury is the most common disease in the musculoskeletal system. The current treatment methods have many limitations, such as poor therapeutic effects, functional loss of donor site, and immune rejection. Tendon tissue engineering provides a new treatment strategy for tendon repair and regeneration. In this review, we made a retrospective analysis of applying mechanical stimulation in tendon tissue engineering, and its potential as a direction of development for future clinical treatment strategies. For this purpose, the following topics are discussed; (1) the context of tendon tissue engineering and mechanical stimulation; (2) the applications of various mechanical stimulations in tendon tissue engineering, as well as their inherent mechanisms; (3) the application of magnetic force and the synergy of mechanical and biochemical stimulation. With this, we aim at clarifying some of the main questions that currently exist in the field of tendon tissue engineering and consequently gain new knowledge that may help in the development of future clinical application of tissue engineering in tendon injury.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.