ReviewJournal of clinical and experimental hepatology
Indian National Association for the Study of Liver Consensus Statement on Acute Liver Failure (Part-2): Management of Acute Liver Failure.
Review in Journal of clinical and experimental hepatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Association between platelet levels and bleeding events in patients with acute-on-chronic liver failure treated with an artificial liver support system.Frontiers in medicine · 2026Article
- Expanding the boundaries of kidney replacement therapy in patients with liver failure.World journal of critical care medicine · 2025Review
- Acute liver failure and liver transplantation.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025Review
- Diagnosis and management of pediatric acute liver failure: consensus recommendations of the Indian Society of Pediatric Gastroenterology, Hepatology, and Nutrition (ISPGHAN).Hepatology international · 2024Review
- Review
- Extra-corporeal non-liver transplant therapies for acute liver failure: Focus on plasma exchange and continuous renal replacement therapy.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024Review
- Critical care management of acute liver failure.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024Review
- Overview of acute liver failure in India.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024Review
- Current progress on the microbial therapies for acute liver failure.Frontiers in microbiology · 2024Review
- Recent advances in anaesthesia for abdominal solid organ transplantation.Indian journal of anaesthesia · 2023Article
- Tropical Fever: Unveiling an Asymptomatic Case of Polycythemia Vera.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2022Article
- Hepatorenal syndrome in acute-on-chronic liver failure with acute kidney injury: more questions requiring discussion.Gastroenterology report · 2021Review
- Acute Liver Failure: Indian Perspective.Clinical liver disease · 2021Review
- COVID-19 vaccines: rapid development, implications, challenges and future prospects.Human cell · 2021Review
- Pediatric Fibrinogen PART II-Overview of Indications for Fibrinogen Use in Critically Ill Children.Frontiers in pediatrics · 2021Review
- Algorithmic Approach to Deranged Liver Functions After Transplantation.Journal of clinical and experimental hepatologyReview
- Rodenticide (Yellow Phosphorus Poison)-Induced Hepatotoxicity in India: Constraints During Management.Journal of clinical and experimental hepatologyArticle
- Improving Transplant-free Survival With Low-volume Plasma Exchange to Treat Children With Rodenticide Induced Hepatotoxicity.Journal of clinical and experimental hepatologyArticle
- Dose of N-acetyl Cysteine in INASL Consensus on Acute Liver Failure (Part 2)-Management.Journal of clinical and experimental hepatologyArticle
- Indian National Association for the Study of Liver (INASL) Guidance Statements for Determining Futility in Liver Transplantation.Journal of clinical and experimental hepatologyReview
Corrections and comments
- Erratum issued
Authors and funding
39 authors at 20 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute liver failure (ALF) is not an uncommon complication of a common disease such as acute hepatitis. Viral hepatitis followed by antituberculosis drug-induced hepatotoxicity are the commonest causes of ALF in India. Clinically, such patients present with appearance of jaundice, encephalopathy, and coagulopathy. Hepatic encephalopathy (HE) and cerebral edema are central and most important clinical event in the course of ALF, followed by superadded infections, and determine the outcome in these patients. The pathogenesis of encephalopathy and cerebral edema in ALF is unique and multifactorial. Ammonia plays a crucial role in the pathogenesis, and several therapies aim to correct this abnormality. The role of newer ammonia-lowering agents is still evolving. These patients are best managed at a tertiary care hospital with facility for liver transplantation (LT). Aggressive intensive medical management has been documented to salvage a substantial proportion of patients. In those with poor prognostic factors, LT is the only effective therapy that has been shown to improve survival. However, recognizing suitable patients with poor prognosis has remained a challenge. Close monitoring, early identification and treatment of complications, and couseling for transplant form the first-line approach to manage such patients. Recent research shows that use of dynamic prognostic models is better for selecting patients undergoing liver transplantation and timely transplant can save life of patients with ALF with poor prognostic factors.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.