ArticleNature2020
eIF2α controls memory consolidation via excitatory and somatostatin neurons.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
82 citing papers in PubMed, 137 citations in OpenAlex.
- Integrative Multi-Omics Analysis Suggests a Proteostasis-Translation-Neuroimmune Axis Underlying Moxifloxacin Associated Cognitive Impairment.Molecular neurobiology · 2026Article
- Learning reorganizes dendritic and stabilizes axon initial segment inhibitory synapses in CA1 pyramidal neurons.Nature communications · 2026Article
- A massively parallel CRISPR-based screening platform for modifiers of neuronal depolarization.Nature communications · 2026Article
- Distinct cell type-specific mechanisms underlie cognitive dysfunction during persistent integrated stress response activation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Neuron type-specific translatomes in dorsal hippocampus during early memory consolidation.Nature communications · 2026Article
- [ModifiedNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026Article
- Article
- Article
- Integrated stress response inhibition rescues inflammation-associated accelerated forgetting of recognition memory in mice.Psychopharmacology · 2026Article
- The ISR downstream effector ATF4 promotes mGluR-dependent long-term depression and associated behavior.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- 4E-BP2-dependent translational control in GABAergic interneurons is required for long-term memory.Molecular neurobiology · 2026Article
- Cell Type-Specific mTORC1 Signaling and Translational Control in Synaptic Plasticity and Memory.Journal of neurochemistry · 2025Review
- Article
- Transcriptome-wide mapping of small ribosomal subunits elucidates scanning mechanisms of translation initiation in the mammalian brain.Communications biology · 2025Article
- Neuron type-specific mRNA translation programs provide a gateway for memory consolidation.bioRxiv : the preprint server for biology · 2025Article
- Emerging roles for integrated stress response signaling in homeostasis.The FEBS journal · 2025Review
- Activity-dependent phosphorylation of CDYL by CDK5 regulates fear memory in mice.Translational psychiatry · 2025Article
- Ribosome association inhibits stress-induced gene mRNA localization to stress granules.Genes & development · 2025Article
- PERK-dependent reciprocal crosstalk between ER and non-centrosomal microtubules coordinates ER architecture and cell shape.Cell reports · 2025Article
- Anterior cingulate cortex parvalbumin and somatostatin interneurons shape social behavior in male mice.Nature communications · 2025Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
30 authors at 10 institutions in 6 countries.
Vijendra SharmaDepartment of Biochemistry, McGill University, Montréal, Québec, Canada. vijendra.sharma@mcgill.ca.
Rapita Sood *Department of Biochemistry, McGill University, Montréal, Québec, Canada.
Abdessattar Khlaifia *Department of Neurosciences, University of Montréal, Montréal, Québec, Canada.
Mohammad Javad Eslamizade *Department of Biochemistry, McGill University, Montréal, Québec, Canada.
Tzu-Yu HungDepartment of Biochemistry, McGill University, Montréal, Québec, Canada.
Danning LouDepartment of Biochemistry, McGill University, Montréal, Québec, Canada.
Azam AsgarihafshejaniDepartment of Neurosciences, University of Montréal, Montréal, Québec, Canada.
Maya LalzarBioinformatics Services Unit, Faculty of Natural Sciences, University of Haifa, Mount Carmel, Haifa, Israel.
Stephen J KinirySchool of Biochemistry and Cell Biology, University College Cork, Cork, T12 XF62, Ireland.ORCID http://orcid.org/0000-0001-5913-7093
Matthew P StokesProteomics Division, Cell Signaling Technology, Danvers, MA, 01923, USA.
Noah CohenDepartment of Biochemistry, McGill University, Montréal, Québec, Canada.
Alissa J NelsonProteomics Division, Cell Signaling Technology, Danvers, MA, 01923, USA.
Kathryn AbellProteomics Division, Cell Signaling Technology, Danvers, MA, 01923, USA.
Anthony P PossematoProteomics Division, Cell Signaling Technology, Danvers, MA, 01923, USA.
Shunit Gal-Ben-AriSagol Department of Neurobiology, University of Haifa, Haifa, Israel.
Vinh T TruongDepartment of Biochemistry, McGill University, Montréal, Québec, Canada.
Peng WangDepartment of Biochemistry, McGill University, Montréal, Québec, Canada.
Adonis YiannakasSagol Department of Neurobiology, University of Haifa, Haifa, Israel.
Fatemeh SaffarzadehDepartment of Neurosciences, University of Montréal, Montréal, Québec, Canada.
A Claudio CuelloDepartment of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada.ORCID http://orcid.org/0000-0003-2143-2745
Karim NaderDepartment of Psychology, McGill University, Montréal, Québec, Canada.
Randal J KaufmanDegenerative Diseases Program, Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-4277-316X
Mauro Costa-MattioliDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0002-9809-4732
Pavel V BaranovSchool of Biochemistry and Cell Biology, University College Cork, Cork, T12 XF62, Ireland.ORCID http://orcid.org/0000-0001-9017-0270
Albert QuintanaDepartment of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Bellaterra, Spain.ORCID http://orcid.org/0000-0003-1674-7160
Elisenda SanzDepartment of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Bellaterra, Spain.ORCID http://orcid.org/0000-0002-7932-8556
Arkady KhoutorskyDepartment of Anesthesia, McGill University, Montréal, Québec, Canada.
Jean-Claude LacailleDepartment of Neurosciences, University of Montréal, Montréal, Québec, Canada.ORCID http://orcid.org/0000-0003-4056-0574
Kobi RosenblumSagol Department of Neurobiology, University of Haifa, Haifa, Israel. kobir@psy.haifa.ac.il.ORCID http://orcid.org/0000-0003-4827-0336
Nahum SonenbergDepartment of Biochemistry, McGill University, Montréal, Québec, Canada. nahum.sonenberg@mcgill.ca.
McGill University Health Centre · CACell Signaling Technology (United States) · USUniversity of Haifa · ILMcGill University · CAUniversité de Montréal · CAUniversitat Autònoma de Barcelona · ESUniversity College Cork · IEBaylor College of Medicine · USCentre for Research on Brain Language and Music · CASanford Burnham Prebys Medical Discovery Institute · US
Funding
The integrated stress response in cognitive disordersR01NS076708 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI PFAFFINGER, PAUL, RAY, RUSSELL S · 2012 to 2025
$7.9M"A Novel Role for the UPR Component, ATF6 in AD-associated Neuroprotective Pathways"R01AG062190 · NIA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI HUANG, TIMOTHY YIKAI, KAUFMAN, RANDAL J. · 2019 to 2023
$4.8MER stress and UPR in non-alcoholic steatohepatitis and hepatocellular carcinomaR01CA198103 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI KAUFMAN, RANDAL J. · 2016 to 2020
$3.4MHomeostatic Role of IRE1a-XBP1-PDI1 in Hepatic Lipid MetabolismR01DK103185 · NIDDK · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI KAUFMAN, RANDAL J. · 2015 to 2019
$2.9MMechanism of ER Protein Misfolding-Induced Mitochondrial DysfunctionR01DK113171 · NIDDK · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI KAUFMAN, RANDAL J. · 2017 to 2020
$2.5MNCI NIH HHS R01 CA198103NIA NIH HHS R01 AG062190NIDDK NIH HHS R01 DK103185NIDDK NIH HHS R01 DK113171NIH HHS 2R01 NS076708-06NINDS NIH HHS R01 NS076708
Abstract
An important tenet of learning and memory is the notion of a molecular switch that promotes the formation of long-term memory
Indexed as
Memory ConsolidationAnimalsCA1 Region, HippocampalEukaryotic Initiation Factor-2Excitatory Postsynaptic PotentialsHippocampusLong-Term PotentiationMaleMemory, Long-TermMiceMice, Inbred C57BLNeural InhibitionNeuronal PlasticityNeuronsParvalbuminsPhosphorylationEukaryotic Initiation Factor-2ParvalbuminsSomatostatin
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.