Evidence map›Paper›PMID 33029001›Full record

ArticleNature2020

Phenotypic landscape of intestinal organoid regeneration.

Ilya Lukonin, Denise Serra, Ludivine Challet Meylan, Katrin Volkmann, Janine Baaten, Rui Zhao, Shelly Meeusen, Karyn Colman, Francisca Maurer, Michael B Stadler and 2 more

Open access · greenAbstract read
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 159 papers.

0numbers the graph read from it
0cells of the map it votes in
159citing papers in PubMed
14.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

159 citing papers in PubMed, 275 citations in OpenAlex.

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99 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Ilya LukoninFriedrich Miescher Institute for Biomedical Research (FMI), Basel, Switzerland.ORCID http://orcid.org/0000-0002-7262-9911
Denise SerraFriedrich Miescher Institute for Biomedical Research (FMI), Basel, Switzerland.ORCID http://orcid.org/0000-0003-0332-8127
Ludivine Challet MeylanFriedrich Miescher Institute for Biomedical Research (FMI), Basel, Switzerland.
Katrin VolkmannFriedrich Miescher Institute for Biomedical Research (FMI), Basel, Switzerland.
Janine BaatenGenomics Institute of the Novartis Research Foundation, San Diego, CA, USA.
Rui ZhaoGenomics Institute of the Novartis Research Foundation, San Diego, CA, USA.
Shelly MeeusenGenomics Institute of the Novartis Research Foundation, San Diego, CA, USA.
Karyn ColmanGenomics Institute of the Novartis Research Foundation, San Diego, CA, USA.
Francisca MaurerFriedrich Miescher Institute for Biomedical Research (FMI), Basel, Switzerland.
Michael B StadlerFriedrich Miescher Institute for Biomedical Research (FMI), Basel, Switzerland.ORCID http://orcid.org/0000-0002-2269-4934
Jeremy JenkinsNovartis Institutes for Biomedical Research Chemical Biology and Therapeutics (CBT), Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-9795-0771
Prisca LiberaliFriedrich Miescher Institute for Biomedical Research (FMI), Basel, Switzerland. prisca.liberali@fmi.ch.ORCID http://orcid.org/0000-0003-0695-6081
Genomics Institute of the Novartis Research Foundation · USFriedrich Miescher Institute · CHUniversity of Basel · CHSIB Swiss Institute of Bioinformatics · CH

Funding

European Research Council 758617Swiss National Science Foundation 157531
6 · The paper itself

Abstract

The development of intestinal organoids from single adult intestinal stem cells in vitro recapitulates the regenerative capacity of the intestinal epithelium

Indexed as

PhenotypeAnimalsCell DifferentiationEnterocytesHomeostasisIntestinal MucosaIntestinesMaleMiceMice, Inbred C57BLOrganoidsReceptors, Retinoic AcidRegenerationSequence Analysis, RNASignal TransductionTranscription, GeneticReceptors, Retinoic AcidTretinoinVitamin A

Identifiers

PMID33029001
PMCPMC7116869
OpenAlexW3092537844

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.