ArticleScientific reports2020
Vascular density with optical coherence tomography angiography and systemic biomarkers in low and high cardiovascular risk patients.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Retinal vascular phenotyping for early detection of coronary artery disease: quantitative assessment and diagnostic modelling.BMJ open · 2026Article
- Correlation between atherogenic index of plasma and retinal vessels in the fundus: a cross-sectional study.European journal of medical research · 2025Article
- The Contingency of Reported sST2 Serum Concentrations with a Protein Detection System (ELISA) from the Same Manufacturer (R&D Biotechne, 2002-2025): An Explanatory Effort by Applied Medical Researchers.Diagnostics (Basel, Switzerland) · 2025Article
- Retinal optical coherence tomography angiography (OCTA) biomarkers of cardiovascular disease: a review article.Eye (London, England) · 2025Review
- Retinal Microangiopathy as a Marker of Coronary Atherosclerotic Heart Disease.International journal of general medicine · 2025Review
- Retinal microstructure and microvasculature in association with brain amyloid burden.Brain communications · 2025Article
- Megahertz multi-parametric ophthalmic OCT system for whole eye imaging.Biomedical optics express · 2024Article
- Review
- Coronary artery disease, its associations with ocular, genetic and blood lipid parameters.Eye (London, England) · 2024Article
- Diabetic choriocapillaris flow deficits affect the outer retina and are related to hemoglobin A1c and systolic blood pressure levels.Scientific reports · 2023Article
- Ocular images-based artificial intelligence on systemic diseases.Biomedical engineering online · 2023Review
- Correlation Between Coronary and Retinal Microangiopathy in Patients With STEMI.Translational vision science & technology · 2023Article
- Article
- Retinal Microvascular Changes in Familial Hypercholesterolemia: Analysis with Swept-Source Optical Coherence Tomography Angiography.Journal of personalized medicine · 2022Article
- Deep Learning of the Retina Enables Phenome- and Genome-Wide Analyses of the Microvasculature.Circulation · 2022Article
- Prediction of Cardiovascular Parameters With Supervised Machine Learning From Singapore "I" Vessel Assessment and OCT-Angiography: A Pilot Study.Translational vision science & technology · 2021Article
- Prevalence of subclinical retinal ischemia in patients with cardiovascular disease - a hypothesis driven study.EClinicalMedicine · 2021Article
- Retinal Microvasculature Causally Affects the Brain Cortical Structure: A Mendelian Randomization Study.Ophthalmology scienceArticle
- Optical coherence tomography angiography in cardiovascular disease.Progress in cardiovascular diseasesReview
- Optical coherence tomography angiography quantitative analysis and 10-year cardiovascular disease risk in the general population.Taiwan journal of ophthalmologyArticle
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We aimed to compare retinal vascular density in Optical Coherence Tomography Angiography (OCT-A) between patients hospitalized for acute coronary syndrome (ACS) and control patients and to investigate correlation with angiogenesis biomarkers. Patients hospitalized for an acute coronary syndrome (ACS) in the Intensive Care Unit were included in the "high cardiovascular risk" group while patients without cardiovascular risk presenting in the Ophthalmology department were included as "control". Both groups had blood sampling and OCT-A imaging. Retina microvascularization density in the superficial capillary plexus was measured on 3 × 3 mm angiograms centered on the macula. Angiopoietin-2, TGF-β1, osteoprotegerin, GDF-15 and ST-2 were explored with ELISA or multiplex method. Overall, 62 eyes of ACS patients and 42 eyes of controls were included. ACS patients had significantly lower inner vessel length density than control patients (p = 0.004). A ROC curve found that an inner vessel length density threshold below 20.05 mm
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