ArticleScientific reports2020
Cerebello-thalamo-cortical network is intrinsically altered in essential tremor: evidence from a resting state functional MRI study.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 5 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed, 5 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Peripheral nerve stimulation for essential tremor: a GRADE-assessed systematic review and meta-analysis.Neurosurgical review · 2026Pooled it
- Clinical and Electrophysiological Heterogeneity of Orthostatic Tremor: An Individual Patient Data Analysis.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026Pooled it
- Altered brain connectivity in hyperkinetic movement disorders: A review of resting-state fMRI.NeuroImage. Clinical · 2023Pooled it
- The Contribution of Neuroimaging to the Understanding of Essential Tremor Pathophysiology: a Systematic Review.Cerebellum (London, England) · 2022Pooled it
- Imaging the Pathophysiology of Essential Tremor-A Systematic Review.Frontiers in neurology · 2021Pooled it
- The Effect of taVNS on the Cerebello-Thalamo-Cortical Pathway: a TMS Study.Cerebellum (London, England) · 2024Trial
- Comparative Analysis of Four Commercially Available Artificial Intelligence Software for Brain Volumetry.Diagnostics (Basel, Switzerland) · 2026Article
- Hand-Specific Engagement of Cerebello-Thalamo-Cortical and Higher-Order Sensorimotor Networks in Essential Tremor: Converging Evidence From GLM and MVPA-Based fMRI Analysis.European journal of neurology · 2026Article
- Decoding pre-movement neural activity from thalamic LFPs for adaptive neurostimulation in tremor patients.Neurocomputing · 2026Article
- Empathy and alexithymia in essential tremor.Frontiers in psychiatry · 2026Article
- Transcranial static magnetic field stimulation of the primary motor cortex in essential tremor: a randomized pilot study.NPJ Parkinson's disease · 2025Article
- Comparative efficacy of PSA and VIM deep brain stimulation in essential tremor: a network and multilevel meta-analysis.Neurosurgical review · 2025Review
- The cerebellar involvement in essential tremor: the connecting roads.Arquivos de neuro-psiquiatria · 2025Review
- Pathophysiological Role of Primary Motor Cortex in Essential Tremor.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Brain Imaging Phenotypes Associated with Polygenic Risk for Essential Tremor.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Targeting the fundamentals for tremors: the frequency and amplitude coding in essential tremor.Journal of biomedical science · 2025Review
- Hyperconnectivity and Connectome Gradient Dysfunction of Cerebello-Thalamo-Cortical Circuitry in Alzheimer's Disease Spectrum Disorders.Cerebellum (London, England) · 2025Article
- Volumetric Assessment and Graph Theoretical Analysis of Thalamic Nuclei in Essential Tremor.Brain and behavior · 2025Article
- Identification of a metabolic brain network characterizing essential tremor.Scientific reports · 2025Article
- MR-guided focused ultrasound thalamotomy modulates cerebello-thalamo-cortical tremor network in essential tremor patients.Frontiers in neurology · 2025Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebello-thalamo-cortical network is suggested to be involved in the pathophysiology of Essential Tremor (ET). 23 patients with ET and 23 matched HC underwent a 3T-MRI with acquisition of a resting state sequence. Connectivity was investigated using a seed-based regression analyses approach. In ET patients were observed: Reduced connectivity between left primary motor cortex (M1) seed and right premotor cortex and cerebellum and bilateral premotor, parietal areas, supplementary motor area (SMA); Increased connectivity between left somatosensory cortex (S1) seed and parietal areas, M1, premotor cortex, SMA; reduced connectivity of this seed with cerebellum. Increased connectivity of SMA seed with premotor cortex and decreased with parietal and precentral areas; Increased connectivity between left thalamus seed and cerebellum; Reduced connectivity between right cerebellum seeds and other cerebellar areas, precentral and premotor areas. ET showed altered connectivity within the cortical sensory-motor network and between cerebral cortex and cerebellum. The increased connectivity between cerebellum and thalamus is consistent with their crucial role in tremor generation. These findings support the dynamical entrainment of multiple central oscillators throughout the cerebello-thalamo-cortical network in ET. This evidence is strengthened by the finding that this network is altered also when the core symptom is absent.
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