Evidence map›Paper›PMID 33028767›Full record

ArticleInternal medicine (Tokyo, Japan)2021

Regression of Lung Squamous Cell Carcinoma after the Withdrawal of Cyclosporin A Combined with Pirfenidone Treatment in a Patient with Idiopathic Pulmonary Fibrosis.

Mari Takahashi, Yukihiro Horio, Takahisa Takihara, Keito Enokida, Masashi Miyaoka, Kenichi Hirabayashi, Kana Ohshinden, Shigeaki Hattori, Fuminari Takahashi, Genki Takahashi and 7 more

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Mari TakahashiDivision of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan.
Yukihiro HorioDivision of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan.
Takahisa TakiharaDivision of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan.
Keito EnokidaDivision of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan.
Masashi MiyaokaDepartment of Pathology, Tokai University School of Medicine, Japan.
Kenichi HirabayashiDepartment of Pathology, Tokai University School of Medicine, Japan.
Kana OhshindenDivision of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan.
Shigeaki HattoriDivision of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan.
Fuminari TakahashiDivision of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan.
Genki TakahashiDivision of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan.
Jun TanakaDivision of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan.
Hiroto TakiguchiDivision of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan.
Kyoko NiimiDivision of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan.
Yoko ItoDivision of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan.
Naoki HayamaDivision of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan.
Tsuyoshi OgumaDivision of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan.
Koichiro AsanoDivision of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan.
Tokai University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 72-year-old man was treated with prednisolone and cyclosporine A for idiopathic pulmonary fibrosis. A nodule with a diameter of 19 mm was found in the right lung and diagnosed as lung squamous cell carcinoma. Anti-cancer treatments were not performed because of the presence of advanced interstitial pneumonia and chronic respiratory failure. Cyclosporine A was tapered to avoid suppression of anti-tumor immunity, and pirfenidone was initiated. Within 2 months, the tumor had shrunk to 10 mm in diameter and remained regressed for 9 months. This is the first report of a non-hematologic solid organ tumor responding to the discontinuation of immunosuppressants.

Indexed as

Carcinoma, Squamous CellIdiopathic Pulmonary FibrosisLung NeoplasmsAgedAnti-Inflammatory Agents, Non-SteroidalCyclosporineHumansLungMalePyridonesTreatment OutcomeAnti-Inflammatory Agents, Non-SteroidalCyclosporinepirfenidonePyridonescyclosporine Aidiopathic pulmonary fibrosisimmunosuppressantslung cancerpirfenidone

Identifiers

PMID33028767
PMCPMC7946518
OpenAlexW3092404457

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.