Evidence map›Paper›PMID 33028766›Full record

ArticleInternal medicine (Tokyo, Japan)2021

Obstructive Jaundice Due to Duodenal Ulcer Induced by Lenvatinib Therapy for Hepatocellular Carcinoma.

Maito Suoh, Atsushi Hagihara, Masafumi Yamamura, Hirotsugu Maruyama, Koichi Taira, Masaru Enomoto, Akihiro Tamori, Yasuhiro Fujiwara, Norifumi Kawada

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. JPGN reports · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Maito SuohDepartment of Hepatology, Graduate School of Medicine, Osaka City University, Japan.
Atsushi HagiharaDepartment of Hepatology, Graduate School of Medicine, Osaka City University, Japan.
Masafumi YamamuraDepartment of Gastroenterology, Graduate School of Medicine, Osaka City University, Japan.
Hirotsugu MaruyamaDepartment of Gastroenterology, Graduate School of Medicine, Osaka City University, Japan.
Koichi TairaDepartment of Gastroenterology, Graduate School of Medicine, Osaka City University, Japan.
Masaru EnomotoDepartment of Hepatology, Graduate School of Medicine, Osaka City University, Japan.
Akihiro TamoriDepartment of Hepatology, Graduate School of Medicine, Osaka City University, Japan.
Yasuhiro FujiwaraDepartment of Gastroenterology, Graduate School of Medicine, Osaka City University, Japan.
Norifumi KawadaDepartment of Hepatology, Graduate School of Medicine, Osaka City University, Japan.
Osaka City University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An 82-year-old man with hepatocellular carcinoma presented with upper abdominal pain, vomiting, and jaundice. He had been taking a standard lenvatinib dose for three months. Although acute cholangitis was suggested, imaging studies failed to detect the biliary obstruction site. An endoscopic examination following discontinuation of lenvatinib and aspirin revealed multiple duodenal ulcers, one of which was formed on the ampulla of Vater and causing cholestasis. Endoscopic biliary drainage and antibiotics improved concomitant Enterobacter cloacae bacteremia. Ulcer healing was confirmed after rabeprazole was replaced with vonoprazan and misoprostol. Our case shows that lenvatinib can induce duodenal ulcers resulting in obstructive jaundice.

Indexed as

Carcinoma, HepatocellularDuodenal UlcerJaundice, ObstructiveLiver NeoplasmsAged, 80 and overHumansMalePhenylurea CompoundsQuinolineslenvatinibPhenylurea CompoundsQuinolinesaspirinduodenal ulcerhepatocellular carcinomalenvatinibobstructive jaundice

Identifiers

PMID33028766
PMCPMC7946507
OpenAlexW3092581307

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.