Evidence map›Paper›PMID 33028717›Full record

ArticleJournal of virology2020

Dongdong Cao, Yunrong Gao, Claire Roesler, Samantha Rice, Paul D'Cunha, Lisa Zhuang, Julia Slack, Anna Antonova, Sarah Romanelli, Bo Liang

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Dongdong CaoDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.
Yunrong GaoDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.
Claire RoeslerDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.
Samantha RiceDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.
Paul D'CunhaDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.
Lisa ZhuangDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.
Julia SlackDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.
Anna AntonovaDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.
Sarah RomanelliDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.
Bo LiangDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA bo.liang@emory.edu.ORCID 0000-0002-5617-9228
Emory University · US

Funding

Structure and Regulation of The Respiratory Syncytial Virus PolymeraseR01GM130950 · NIGMS · EMORY UNIVERSITY · PI Bo Liang · 2019 to 2026
$3.3M
NIGMS NIH HHS R01 GM130950
6 · The paper itself

Abstract

Respiratory syncytial virus (RSV) is a nonsegmented negative-sense (NNS) RNA virus and shares a similar RNA synthesis strategy with other members of NNS RNA viruses, such as measles, rabies virus, and Ebola virus. RSV RNA synthesis is catalyzed by a multifunctional RNA-dependent RNA polymerase (RdRP), which is composed of a large (L) protein that catalyzes three distinct enzymatic functions and an essential coenzyme phosphoprotein (P). Here, we successfully prepared highly pure, full-length, wild-type and mutant RSV polymerase (L-P) complexes. We demonstrated that the RSV polymerase could carry out both

Indexed as

Base SequenceMutationPromoter Regions, GeneticRespiratory Syncytial Virus, HumanRNA-Dependent RNA PolymeraseRNA, ViralViral Replicase Complex ProteinsVirus ReplicationRNA-Dependent RNA PolymeraseRNA, ViralViral Replicase Complex Proteinsin vitropolymerasesprimer-based RNA elongationpromoter mappingrespiratory syncytial virus

Identifiers

PMID33028717
PMCPMC7737744
OpenAlexW3092205204

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.