Evidence map›Paper›PMID 33028711›Full record

ArticleJournal of virology2020

Deletion of Murine Gammaherpesvirus Gene

Shana M Owens, Darby G Oldenburg, Douglas W White, J Craig Forrest

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Shana M OwensDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Darby G OldenburgGundersen Health System, La Crosse, Wisconsin, USA.
Douglas W WhiteGundersen Health System, La Crosse, Wisconsin, USA.
J Craig ForrestDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA JCForrest@uams.edu.
Gundersen Health System · USUniversity of Arkansas for Medical Sciences · USWinthrop Rockefeller Foundation · US

Funding

Expanding Translational Research in ArkansasUL1TR003107 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI JAMES, LAURA P · 2019 to 2023
$21.6M
Study of the Cell-specific Inflammasome Responses During Defense Against Gram-negative BacteriaP20GM103625 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI SMELTZER, MARK S · 2012 to 2021
$21.5M
Gammaherpesvirus interactions with host tumor suppressor p53R01CA167065 · NCI · UNIV OF ARKANSAS FOR MED SCIS · PI James Craig Forrest · 2014 to 2026
$3.8M
J. NRSA TrainingTL1TR003109 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI SEXTON, KEVIN WAYNE · 2019 to 2023
$1.5M
NCATS NIH HHS TL1 TR003109NCATS NIH HHS UL1 TR003107NCI NIH HHS R01 CA167065NIGMS NIH HHS P20 GM103625
6 · The paper itself

Abstract

Gammaherpesviruses (GHVs) are DNA tumor viruses that establish lifelong, chronic infections in lymphocytes of humans and other mammals. GHV infections are associated with numerous cancers, especially in immunocompromised hosts. While it is known that GHVs utilize host germinal center (GC) B cell responses during latency establishment, an understanding of how viral gene products function in specific B cell subsets to regulate this process is incomplete. Using murine gammaherpesvirus 68 (MHV68) as a small-animal model to define mechanisms of GHV pathogenesis

Indexed as

Virus ActivationAnimalsAntigens, CD19B-LymphocytesCell DifferentiationCell ProliferationCytidine DeaminaseGerminal CenterHerpesviridae InfectionsLymphoid TissueMiceRhadinovirusViral ProteinsVirus LatencyAntigens, CD19CD19 antigen, mouseCytidine DeaminaseM2 protein, murine gammaherpesvirus 68Viral Proteinsactivation-induced cytidine deaminaseB cellsgammaherpesviruslatencyM2MHV68murid herpesvirus 4murine gammaherpesvirus 68reactivationtumor virus

Identifiers

PMID33028711
PMCPMC7737732
OpenAlexW3092004878

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.