ArticleGut2021
Multiplexed endoscopic imaging of Barrett's neoplasia using targeted fluorescent heptapeptides in a phase 1 proof-of-concept study.
Abstract readClinical Trial, Phase I
In one paragraph
Article in Gut, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Near-infrared fluorescence imaging with an MET-targeting probe for biopsy site selection in patients with oral potentially malignant disorders.Cell reports. Medicine · 2025Trial
- Detection of Barrett's neoplasia with a near-infrared fluorescent heterodimeric peptide.Endoscopy · 2022Trial
- Chemical fluorophores for fluorescence lifetime imaging.Chemical Society reviews · 2026Review
- Preclinical and pilot clinical evaluation of novel dual-modality pet/fluorescence probes targeting FAP for accurate tumor margin delineation.European journal of nuclear medicine and molecular imaging · 2026Article
- The biology and therapeutic implications of heterogeneity in Barrett oesophagus and oesophageal adenocarcinoma.Nature reviews. Clinical oncology · 2026Review
- Optical and Optoacoustic Imaging.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026Review
- Molecularly targeted photoacoustic endoscopy with fiber-scanning side-view probe for in vivo staging of early mucosal tumors.Biosensors & bioelectronics · 2025Article
- Review
- Transforming Gastrointestinal Diagnosis with Molecular Endoscopy: Challenges and Opportunities.International journal of molecular sciences · 2025Review
- Targeting c-MET for Endoscopic Detection of Dysplastic Lesions within Barrett's Esophagus Using EMI-137 Fluorescence Imaging.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025Article
- Tissue-seeking dyes for in vivo applications.Smart molecules : open access · 2024Review
- Multispectral fluorescence imaging of EGFR and PD-L1 for precision detection of oral squamous cell carcinoma: a preclinical and clinical study.BMC medicine · 2024Article
- NIR-II light in clinical oncology: opportunities and challenges.Nature reviews. Clinical oncology · 2024Review
- Gastrointestinal Tract and Kidney Injury Pathogenesis in Post-COVID-19 Syndrome.Current diabetes reviews · 2024Review
- Wide-field endoscope accessory for multiplexed fluorescence imaging.Scientific reports · 2023Article
- Fluorescent Probes for Imaging in Humans: Where Are We Now?ACS nano · 2023Review
- Flexible fiber cholangioscope for detection of near-infrared fluorescence.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2023Article
- Highlighting the Undetectable - Fluorescence Molecular Imaging in Gastrointestinal Endoscopy.Molecular imaging and biology · 2023Review
- Application of near-infrared fluorescence imaging in theranostics of gastrointestinal tumors.Gastroenterology report · 2023Review
- Development of Advanced Imaging and Molecular Imaging for Barrett's Neoplasia.Diagnostics (Basel, Switzerland) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Jing ChenInternal Medicine, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0001-8863-2843
Yang JiangBiomedical Engineering, University of Washington, Seattle, WA, USA.
Tse-Shao ChangMechanical Engineering, University of Michigan, Ann Arbor, Michigan, USA.
Bishnu JoshiInternal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Juan ZhouInternal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Joel H RubensteinInternal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Erik J WamstekerInternal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Richard S KwonInternal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Henry AppelmanPathology, University of Michigan, Ann Arbor, Michigan, USA.
David G BeerThoracic Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Danielle K TurgeonInternal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Eric J SeibelMechanical Engineering, University of Washington, Seattle, WA, USA.
Thomas D WangInternal Medicine, University of Michigan, Ann Arbor, Michigan, USA thomaswa@umich.edu.ORCID 0000-0001-9182-9620
Funding
University of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OMARY, BISHR · 1986 to 2021
$22.5MValidation & Pathology CoreU54CA163059 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RUBENSTEIN, JOEL H, WANG, THOMAS D · 2011 to 2022
$12.1MMultiplexed imaging of biliary intra-epithelial neoplasiaR01CA200007 · NCI · UNIVERSITY OF WASHINGTON · PI SEIBEL, ERIC J, WANG, THOMAS D · 2015 to 2019
$2.9MEarly Detection of Colorectal Cancer on Near-Infrared Molecular EndoscopyR01CA193377 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WANG, THOMAS D · 2016 to 2020
$2.1MMultiplexed Multi-Modal Endoscopic Imaging of Cancer BiomarkersU01CA189291 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WANG, THOMAS D · 2015 to 2018
$1.4MNCI NIH HHS R01 CA193377NCI NIH HHS R01 CA200007NCI NIH HHS U01 CA189291NCI NIH HHS U54 CA163059NIDDK NIH HHS P30 DK034933
Abstract
PubMed holds no abstract for this paper.
Indexed as
AgedAged, 80 and overBarrett EsophagusCarbocyaninesErb-b2 Receptor Tyrosine KinasesErbB ReceptorsEsophagoscopyFalse Positive ReactionsFemaleFluorescent DyesHumansIndolesMaleMiddle AgedMolecular ImagingPeptidesCarbocyaninescyanine dye 5EGFR protein, humanERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesErbB ReceptorsFluorescent DyesIndolesIRDye800PeptidesBarrett's oesophagusclinical trialsfluorescence endoscopyimagingpeptides
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.