Evidence map›Paper›PMID 33028634›Full record

ArticleThe Journal of biological chemistry2020

Stop codon read-through of mammalian

Lekha E Manjunath, Anumeha Singh, Sarthak Sahoo, Ashutosh Mishra, Jinsha Padmarajan, Chaithanya G Basavaraju, Sandeep M Eswarappa

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Lekha E ManjunathDepartment of Biochemistry, Indian Institute of Science, Bengaluru, Karnataka, India.
Anumeha SinghDepartment of Biochemistry, Indian Institute of Science, Bengaluru, Karnataka, India.
Sarthak SahooDepartment of Biochemistry, Indian Institute of Science, Bengaluru, Karnataka, India.
Ashutosh MishraDepartment of Biochemistry, Indian Institute of Science, Bengaluru, Karnataka, India.
Jinsha PadmarajanDepartment of Biochemistry, Indian Institute of Science, Bengaluru, Karnataka, India.
Chaithanya G BasavarajuDepartment of Biochemistry, Indian Institute of Science, Bengaluru, Karnataka, India.
Sandeep M EswarappaDepartment of Biochemistry, Indian Institute of Science, Bengaluru, Karnataka, India. Electronic address: sandeep@iisc.ac.in.
Indian Institute of Science Bangalore · IN

Funding

Wellcome Trust
6 · The paper itself

Abstract

Stop codon read-through (SCR) is a process of continuation of translation beyond a stop codon. This phenomenon, which occurs only in certain mRNAs under specific conditions, leads to a longer isoform with properties different from that of the canonical isoform.

Indexed as

Membrane Potential, MitochondrialProtein Biosynthesis3' Untranslated RegionsAnimalsAortaBase SequenceCattleCodon, TerminatorCRISPR-Cas SystemsEndothelium, VascularHEK293 CellsHumansMitochondrial Membrane Transport ProteinsProtein IsoformsRibosomesRNA, Messenger3' Untranslated RegionsCodon, TerminatorMitochondrial Membrane Transport ProteinsMTCH2 protein, humanProtein IsoformsRNA, Messengercodonmitochondriamitochondrial membrane potentialmRNAMTCH2protein degradationribosomestopstop codontranslational read-throughtranslation control

Identifiers

PMID33028634
PMCPMC7863902
OpenAlexW3091840596

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.