Evidence map›Paper›PMID 33028610›Full record

ArticleDevelopment (Cambridge, England)2020

The Arp2/3 complex is crucial for colonisation of the mouse skin by melanoblasts.

Vassilis Papalazarou, Karthic Swaminathan, Farah Jaber-Hijazi, Heather Spence, Ines Lahmann, Colin Nixon, Manuel Salmeron-Sanchez, Hans-Henning Arnold, Klemens Rottner, Laura M Machesky

Open access · hybridAbstract read
In one paragraph

Article in Development (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  8. Cancers · 2022
    Article
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  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Vassilis PapalazarouCRUK Beatson Institute, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.ORCID 0000-0003-3206-401X
Karthic SwaminathanCRUK Beatson Institute, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.ORCID 0000-0002-0981-7549
Farah Jaber-HijaziCRUK Beatson Institute, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.ORCID 0000-0001-6094-751X
Heather SpenceCRUK Beatson Institute, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.
Ines LahmannCell and Molecular Biology, Institute of Biochemistry and Biotechnology, Technische Universität Braunschweig, Spielmannstrasse 7, 38106 Braunschweig, Germany.
Colin NixonCRUK Beatson Institute, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.
Manuel Salmeron-SanchezCentre for the Cellular Microenvironment, University of Glasgow, Glasgow G12 8LT, UK.ORCID 0000-0002-8112-2100
Hans-Henning ArnoldCell and Molecular Biology, Institute of Biochemistry and Biotechnology, Technische Universität Braunschweig, Spielmannstrasse 7, 38106 Braunschweig, Germany.
Klemens RottnerDivision of Molecular Cell Biology, Zoological Institute, Technische Universität Braunschweig, Spielmannstrasse 7, 38106 Braunschweig, Germany.ORCID 0000-0003-4244-4198
Laura M MacheskyCRUK Beatson Institute, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK l.machesky@beatson.gla.ac.uk.ORCID 0000-0002-7592-9856
Cancer Research UK Scotland Institute · GBCancer Research UK · GBTechnische Universität Braunschweig · DEHelmholtz Centre for Infection Research · DEUniversity of Glasgow · GB

Funding

Cancer Research UK 24452Cancer Research UK A18076Cancer Research UK C596/A17196Medical Research Council MR/R017255/1
6 · The paper itself

Abstract

The Arp2/3 complex is essential for the assembly of branched filamentous actin, but its role in physiology and development is surprisingly little understood. Melanoblasts deriving from the neural crest migrate along the developing embryo and traverse the dermis to reach the epidermis, colonising the skin and eventually homing within the hair follicles. We have previously established that Rac1 and Cdc42 direct melanoblast migration

Indexed as

Cell AdhesionCell ProliferationSkin PigmentationActin-Related Protein 2-3 ComplexAnimalscdc42 GTP-Binding ProteinCell LineExtracellular MatrixMelanocytesMiceNeuropeptidesrac1 GTP-Binding ProteinSkinActin-Related Protein 2-3 Complexcdc42 GTP-Binding ProteinCdc42 protein, mouseNeuropeptidesrac1 GTP-Binding ProteinRac1 protein, mouseActin cytoskeletonArp2/3MelanoblastsMigrationSkin pigmentation

Identifiers

PMID33028610
PMCPMC7687863
OpenAlexW3092276813

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.