Evidence map›Paper›PMID 33028607›Full record

ArticleDevelopment (Cambridge, England)2020

Differential abilities to engage inaccessible chromatin diversify vertebrate Hox binding patterns.

Milica Bulajić, Divyanshi Srivastava, Jeremy S Dasen, Hynek Wichterle, Shaun Mahony, Esteban O Mazzoni

Abstract read
In one paragraph

Article in Development (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. TheiScience · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Hox genes in development and beyond.Development (Cambridge, England) · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. Micromanagement ofJournal of developmental biology · 2022
    Review
  20. Transcriptional Regulation and Implications for ControllingJournal of developmental biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Milica BulajićDepartment of Biology, New York University, New York, NY 10003, USA mb5443@nyu.edu eom204@nyu.edu.ORCID 0000-0001-8592-0022
Divyanshi SrivastavaCenter for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.
Jeremy S DasenNeuroscience Institute, Department of Neuroscience and Physiology, New York University School of Medicine, New York, NY 10016, USA.
Hynek WichterleDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0002-7817-0080
Shaun MahonyCenter for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.ORCID 0000-0002-2641-1807
Esteban O MazzoniDepartment of Biology, New York University, New York, NY 10003, USA mb5443@nyu.edu eom204@nyu.edu.ORCID 0000-0001-8994-681X

Funding

Genetic Control of Circuit Assembly in the Vertebrate Spinal Cord - Diversity SupplementR35NS116858 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JEREMY S DASEN · 2020 to 2026
$6.7M
Understanding CTCF Boundaries Controlling Hox Gene ExpressionR01NS100897 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Esteban Orlando Mazzoni, DANNY REINBERG · 2018 to 2026
$4.1M
Transcriptional Control of Motor Neuron Identity and Connectivity. - Renewal - 1R01NS062822 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DASEN, JEREMY S · 2009 to 2019
$3.9M
Distal enhancers controlling motor neuron gene expression programR01NS109217 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WICHTERLE, HYNEK · 2019 to 2022
$2.1M
Transcriptional Control of Motor Neuron MaturationR01NS116141 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WICHTERLE, HYNEK · 2020 to 2024
$1.9M
Molecular mechanisms of direct neuronal programmingR01HD079682 · NICHD · NEW YORK UNIVERSITY · PI MAZZONI, ESTEBAN ORLANDO · 2014 to 2018
$1.5M
A 2D segmentation method for jointly characterizing epigenetic dynamics in multiple cell linesR01GM121613 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI MAHONY, SHAUN AENGUS · 2017 to 2019
$1.0M
NICHD NIH HHS R01 HD079682NIGMS NIH HHS R01 GM121613NINDS NIH HHS R01 NS062822NINDS NIH HHS R01 NS100897NINDS NIH HHS R01 NS109217NINDS NIH HHS R01 NS116141NINDS NIH HHS R35 NS116858
6 · The paper itself

Abstract

Although Hox genes encode for conserved transcription factors (TFs), they are further divided into anterior, central and posterior groups based on their DNA-binding domain similarity. The posterior Hox group expanded in the deuterostome clade and patterns caudal and distal structures. We aimed to address how similar Hox TFs diverge to induce different positional identities. We studied Hox TF DNA-binding and regulatory activity during an

Indexed as

Cell DifferentiationEmbryonic DevelopmentGene Expression Regulation, DevelopmentalAnimalsCell LineChromatinHomeodomain ProteinsMiceMotor NeuronsTranscription FactorsChromatinHomeodomain ProteinsHox 3.6 protein, mouseHoxc9 protein, mouseTranscription FactorsBindingChromatinHoxPatterningSpinal cordStem cell differentiation

Identifiers

PMID33028607
PMCPMC7710020

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.