Evidence map›Paper›PMID 33028588›Full record

Trial reportBMJ (Clinical research ed.)2020

Effect of exercise training for five years on all cause mortality in older adults-the Generation 100 study: randomised controlled trial.

Dorthe Stensvold, Hallgeir Viken, Sigurd L Steinshamn, Håvard Dalen, Asbjørn Støylen, Jan P Loennechen, Line S Reitlo, Nina Zisko, Fredrik H Bækkerud, Atefe R Tari and 13 more

2 registry-linked trialsOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ (Clinical research ed.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 87 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 11 pooled it
21.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01666340 naactive not recruitingnot on this map

Generation 100: How Exercise Affects Mortality and Morbidity in the Elderly: A Randomized Control Study

TypeinterventionalSponsorNorwegian University of Science and TechnologyRan2012 to 2026Enrolled1,567ConditionsAgeingArmsExercise intervention
NCT07785765 naenrolling by invitationnot on this mapstarted 2027, after this paper: background citation

Norwegian Danish Spontaneous Coronary Artery Dissection Exercise Study

TypeinterventionalSponsorOslo University HospitalRan2027 to 2028Enrolled120ConditionsSpontaneous Coronary Artery Dissection, Myocardial Infarction (MI), High Intensity Interval TrainingArmsHigh intensity interval training (HIIT)
3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 11 syntheses or guidelines pooled it, 142 citations in OpenAlex.

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27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Commented on by
    2021
5 · Who and what money

Authors and funding

23 authors at 4 institutions in 2 countries.

Dorthe StensvoldDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, Post Box 8905, 7491 Trondheim, Norway.
Hallgeir VikenDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, Post Box 8905, 7491 Trondheim, Norway.
Sigurd L SteinshamnDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, Post Box 8905, 7491 Trondheim, Norway.
Håvard DalenDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, Post Box 8905, 7491 Trondheim, Norway.
Asbjørn StøylenDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, Post Box 8905, 7491 Trondheim, Norway.
Jan P LoennechenDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, Post Box 8905, 7491 Trondheim, Norway.
Line S ReitloDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, Post Box 8905, 7491 Trondheim, Norway.
Nina ZiskoDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, Post Box 8905, 7491 Trondheim, Norway.
Fredrik H BækkerudDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, Post Box 8905, 7491 Trondheim, Norway.
Atefe R TariDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, Post Box 8905, 7491 Trondheim, Norway.
Silvana B SandbakkDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, Post Box 8905, 7491 Trondheim, Norway.
Trude CarlsenDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, Post Box 8905, 7491 Trondheim, Norway.
Jan E IngebrigtsenDepartment of Sociology and Political Science, Faculty of Social Sciences and Technology Management, NTNU-Norwegian University of Science and Technology, Trondheim, Norway.
Stian LydersenRegional Centre for Child and Youth Mental Health and Child Welfare, NTNU-Norwegian University of Science and Technology, Trondheim, Norway.
Erney MattssonDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, Post Box 8905, 7491 Trondheim, Norway.
Sigmund A AnderssenDepartment of Sports Medicine, The Norwegian School of Sport Sciences, Oslo, Norway.
Maria A Fiatarone SinghExercise Health and Performance Faculty Research Group, Faculty of Health Sciences, The University of Sydney, Lidcombe, Australia.
Jeff S CoombesSchool of Human Movement and Nutrition Science, University of Queensland, Queensland, Australia.
Eirik SkogvollDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, Post Box 8905, 7491 Trondheim, Norway.
Lars J VattenDepartment of Public Health and General Practice, Faculty of Medicine, NTNU-Norwegian University of Science and Technology, Trondheim, Norway.
Jorunn L HelbostadDepartment of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, Trondheim, Norway.
Øivind RognmoDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, Post Box 8905, 7491 Trondheim, Norway.
Ulrik WisløffDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, Post Box 8905, 7491 Trondheim, Norway ulrik.wisloff@ntnu.no.ORCID 0000-0002-7211-3587
Norwegian University of Science and Technology · NOThe University of Queensland · AUNorwegian School of Sport Sciences · NOThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the effect of five years of supervised exercise training compared with recommendations for physical activity on mortality in older adults (70-77 years).

designRandomised controlled trial.

settingGeneral population of older adults in Trondheim, Norway.

participants1567 of 6966 individuals born between 1936 and 1942.

interventionParticipants were randomised to two sessions weekly of high intensity interval training at about 90% of peak heart rate (HIIT, n=400), moderate intensity continuous training at about 70% of peak heart rate (MICT, n=387), or to follow the national guidelines for physical activity (n=780; control group); all for five years.

main outcome measureAll cause mortality. An exploratory hypothesis was that HIIT lowers mortality more than MICT.

resultsMean age of the 1567 participants (790 women) was 72.8 (SD 2.1) years. Overall, 87.5% of participants reported to have overall good health, with 80% reporting medium or high physical activity levels at baseline. All cause mortality did not differ between the control group and combined MICT and HIIT group. When MICT and HIIT were analysed separately, with the control group as reference (observed mortality of 4.7%), an absolute risk reduction of 1.7 percentage points was observed after HIIT (hazard ratio 0.63, 95% confidence interval 0.33 to 1.20) and an absolute increased risk of 1.2 percentage points after MICT (1.24, 0.73 to 2.10). When HIIT was compared with MICT as reference group an absolute risk reduction of 2.9 percentage points was observed (0.51, 0.25 to 1.02) for all cause mortality. Control participants chose to perform more of their physical activity as HIIT than the physical activity undertaken by participants in the MICT group. This meant that the controls achieved an exercise dose at an intensity between the MICT and HIIT groups.

conclusionThis study suggests that combined MICT and HIIT has no effect on all cause mortality compared with recommended physical activity levels. However, we observed a lower all cause mortality trend after HIIT compared with controls and MICT.

trial registrationClinicalTrials.gov NCT01666340.

Indexed as

AgingExercisePhysical Functional PerformanceAgedCause of DeathFemaleHeart RateHigh-Intensity Interval TrainingHumansMaleMortalityOutcome Assessment, Health CarePhysical FitnessRisk Reduction Behavior

Identifiers

PMID33028588
PMCPMC7539760
OpenAlexW3091993604

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.