Evidence map›Paper›PMID 33028554›Full record

ArticleBMJ open2020

INtravenous Contrast computed tomography versus native computed tomography in patients with acute Abdomen and impaired Renal functiOn (INCARO): a multicentre, open-label, randomised controlled trial - study protocol.

Panu Räty, Panu Mentula, Hanna Lampela, Taina Nykänen, Ilkka Helanterä, Mikko Haapio, Tiina Lehtimäki, Markus B Skrifvars, Suvi T Vaara, Ari Leppäniemi and 1 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04196244 (INtravenous Contrast Computed Tomography Versus Native Computed Tomography in Patients With Acute Abdomen and Impaired Renal functiOn), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04196244 phase4recruitingnot on this map

INtravenous Contrast Computed Tomography Versus Native Computed Tomography in Patients With Acute Abdomen and Impaired Renal functiOn (INCARO) - a Multicentre, Open-label, Randomised Controlled Trial

TypeinterventionalSponsorHelsinki University Central HospitalRan2020 to 2033Enrolled994ConditionsAcute Abdomen, Radiocontrast NephropathyArmsAbdominal or body CT with intravenous contrast, Abdominal or body CT without intravenous contrast (native CT)
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Panu RätyDepartment of Abdominal Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0001-6088-4547
Panu MentulaDepartment of Abdominal Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Hanna LampelaDepartment of Abdominal Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Taina NykänenDepartment of Surgery, Hyvinkää Hospital, Hyvinkää, Finland.
Ilkka HelanteräDepartment of Transplantation and Liver Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Mikko HaapioNephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Tiina LehtimäkiDepartment of Radiology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Markus B SkrifvarsDepartment of Emergency Care and Services, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Suvi T VaaraDivision of Intensive Care Medicine, Department of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Ari LeppäniemiDepartment of Abdominal Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Ville SallinenDepartment of Abdominal Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland ville.sallinen@helsinki.fi.
University of Helsinki · FIHyvinkää Hospital · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCT is the primary imaging option for acute abdominal pain in adults. Intravenous (IV) contrast media use improves CT quality but may cause post-contrast acute kidney injury (PC-AKI). Retrospective studies show no association between reduced baseline renal function and IV contrast CT, but, to our knowledge, no data from randomised controlled trials exist. METHODS AND ANALYSIS: The INCARO (INtravenous Contrast computed tomography versus native computed tomography in patients with acute Abdomen and impaired Renal functiOn) trial is a multicentre, open-label, parallel group, superiority, individually randomised controlled trial comparing IV contrast-enhanced CT to native CT in patients requiring emergency abdominal or body CT with impaired renal function defined as an estimated glomerular filtration rate (eGFR) of 15 to 45 mL/min/1.73 m ETHICS AND DISSEMINATION: The Ethics Committee of Helsinki University Hospital approved the study. The findings will be disseminated in peer-reviewed academic journals. TRIAL REGISTRATION NUMBER: NCT04196244.

Indexed as

Abdomen, AcuteAcute Kidney InjuryAdultEquivalence Trials as TopicHumansMulticenter Studies as TopicRandomized Controlled Trials as TopicRenal Replacement TherapyRetrospective StudiesTomography, X-Ray Computedaccident & emergency medicineacute renal failureadult intensive & critical careadult surgerycomputed tomography

Identifiers

PMID33028554
PMCPMC7539602
OpenAlexW3092250626

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.