ArticleScience advances2020
Spatial localization of charged molecules by salt ions in oil-confined water microdroplets.
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 48 citations in OpenAlex.
- Rapid spontaneous generation of organosulfur from inorganic sulfur in atmospheric microdroplets.Nature communications · 2026Article
- Surface tension measurements reveal charge-driven surfactant depletion in microdroplets approaching the Rayleigh limit.Chemical science · 2026Article
- Aging-dependent evolving electrochemical potentials of biomolecular condensates regulate their physicochemical activities.Nature chemistry · 2025Article
- Enhanced Biphasic Reactions in Amphiphilic Silica Mesopores.The journal of physical chemistry. C, Nanomaterials and interfaces · 2024Article
- Review
- Article
- Imaging of pH distribution inside individual microdroplet by stimulated Raman microscopy.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Spatial reorganization of analytes in charged aqueous microdroplets.Chemical science · 2022Article
- Oxidation of Cysteine by Electrogenerated Hexacyanoferrate(III) in Microliter Droplets.Langmuir : the ACS journal of surfaces and colloids · 2022Article
- Enzyme-photo-coupled catalysis in gas-sprayed microdroplets.Chemical science · 2022Article
- Investigating water/oil interfaces with opto-thermophoresis.Nature communications · 2022Article
- Condensing water vapor to droplets generates hydrogen peroxide.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cells contain more than 100 mM salt ions that are typically confined to dimensions of 5 to 10 micrometers by a hydrophobic cellular membrane. We found that in aqueous microdroplets having the same size as cells and that are confined in hydrocarbon oil, negatively charged molecules were distributed rather uniformly over the interior of the microdroplet, whereas positively charged molecules were localized at and near the surface. However, the addition of salt (NaCl) to the microdroplet caused all charged molecules to be localized near the oil-water interface. This salt-induced relocalization required less salt concentration in microdroplets compared to bulk water. Moreover, the localization became more prominent as the size of the microdroplet was reduced. The relocatization also critically depended on the type of oil. Our results imply that salt ions and different hydrophobic interfaces together may govern the local distribution of charged biomolecules in confined intracellular environments.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.