Evidence map›Paper›PMID 33028433›Full record

ReviewPsychological medicine2020

Why we need more research into the placebo response in psychiatry.

Nathan T M Huneke, Nic van der Wee, Matthew Garner, David S Baldwin

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Psychological medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nathan T M HunekeClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.ORCID 0000-0001-5981-6707
Nic van der WeeDepartment of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.
Matthew GarnerClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
David S BaldwinClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.

Funding

Medical Research Council MR/T000902/1
6 · The paper itself

Abstract

Placebos are not inert, but exert measurable biological effects. The placebo response in psychiatric illness is important and clinically relevant, but remains poorly understood. In this paper, we review current knowledge about the placebo response in psychiatric medicine and identify research directions for the future. We argue that more research is needed into the placebo response in psychiatric medicine for three broad reasons. First, awareness of factors that cause placebo response, for whom, and when, within clinical trials will allow us to better evidence efficacy of new treatments. Second, by understanding how placebo mechanisms operate in the clinic, we can take advantage of these to optimise the effects of current treatments. Finally, exploring the biological mechanisms of placebo effects might reveal tractable targets for novel treatment development.

Indexed as

Placebo EffectPlacebosClinical Trials as TopicHumansMental DisordersPsychiatryPlacebosplaceboPlacebo responsepsychiatric medicinepsychotropic trials

Identifiers

PMID33028433
PMCPMC7610180

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.