ArticleParasites & vectors2020
Assessing the acoustic behaviour of Anopheles gambiae (s.l.) dsxF mutants: implications for vector control.
Article in Parasites & vectors, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Pickpocket315 affects male mating behavior in the yellow fever mosquito Aedes aegypti.G3 (Bethesda, Md.) · 2026Article
- Using a female-specific isoform ofiScience · 2025Article
- A mosquito-inspired theoretical framework for acoustic signal detection.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Mosquitoes integrate visual and acoustic cues to mediate conspecific interactions in swarms.Current biology : CB · 2024Article
- Population suppression by release of insects carrying a dominant sterile homing gene drive targeting doublesex in Drosophila.Nature communications · 2024Article
- MACSFeD-a database of mosquito acoustic communication and swarming features.Database : the journal of biological databases and curation · 2024Article
- Differences in maleiScience · 2024Article
- Article
- Targeting Sex Determination to Suppress Mosquito Populations.bioRxiv : the preprint server for biology · 2023Article
- Targeting Sex Determination to Suppress Mosquito Populations.Research square · 2023Article
- Hitting the right note at the right time: Circadian control of audibility inScience advances · 2022Article
- Serotonin modulation in the maleFrontiers in physiology · 2022Article
- Harmonic convergence coordinates swarm mating by enhancing mate detection in the malaria mosquito Anopheles gambiae.Scientific reports · 2021Article
- Mosquito Sexual Selection and Reproductive Control Programs.Trends in parasitology · 2021Review
- Adequacy and sufficiency evaluation of existing EFSA guidelines for the molecular characterisation, environmental risk assessment and post-market environmental monitoring of genetically modified insects containing engineered gene drives.EFSA journal. European Food Safety Authority · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundRelease of gene-drive mutants to suppress Anopheles mosquito reproduction is a promising method of malaria control. However, many scientific, regulatory and ethical questions remain before transgenic mosquitoes can be utilised in the field. At a behavioural level, gene-drive carrying mutants should be at least as sexually attractive as the wildtype populations they compete against, with a key element of Anopheles copulation being acoustic courtship. We analysed sound emissions and acoustic preference in a doublesex mutant previously used to collapse Anopheles gambiae (s.l.) cages.
methodsAnopheles rely on flight tones produced by the beating of their wings for acoustic mating communication. We assessed the impact of disrupting a female-specific isoform of the doublesex gene (dsxF) on the wing beat frequency (WBF; measured as flight tone) of males (XY) and females (XX) in homozygous dsxF
resultsA previous study showed an altered phenotype only for dsxF
conclusionsA prerequisite for anopheline copulation is the phonotactic attraction of males towards female flight tones within mating swarms. Reductions in mutant acoustic attractiveness diminish their mating efficiency and thus the efficacy of population control efforts. Caged population assessments may not successfully reproduce natural mating scenarios. We propose to amend existing testing protocols to better reflect competition between mutants and target populations. Our findings confirm that dsxF disruption has no effect on males; for some phenotypic traits, such as female WBFs, the effects of dsxF appear dose-dependent rather than haplosufficient.
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