Evidence map›Paper›PMID 33028393›Full record

ArticleSystematic reviews2020

The risk of cardiovascular disease in women after miscarriage, stillbirth, and therapeutic abortion: a protocol for a systematic review and meta-analysis.

Charlotte Muehlschlegel, Harry Kyriacou, Abdulrahman Al-Mohammad, Lowri A Foster-Davies, Fiona Simmons-Jones, Clare Oliver-Williams

Open access · goldAbstract read
In one paragraph

Article in Systematic reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Charlotte MuehlschlegelSchool of Clinical Medicine, University of Cambridge, Cambridge, England.
Harry KyriacouSchool of Clinical Medicine, University of Cambridge, Cambridge, England.
Abdulrahman Al-MohammadSchool of Clinical Medicine, University of Cambridge, Cambridge, England.
Lowri A Foster-DaviesSchool of Clinical Medicine, University of Cambridge, Cambridge, England.
Fiona Simmons-JonesEssex County Council, County Hall, Chelmsford, Essex, CM1 1QH, England.
Clare Oliver-WilliamsHomerton College, University of Cambridge, Cambridge, England. cto21@cam.ac.uk.ORCID 0000-0002-3573-2426
University of Cambridge · GBEssex County Council · GB

Funding

British Heart Foundation RG/13/13/30194British Heart Foundation RG/18/13/33946Medical Research Council MR/L003120/1
6 · The paper itself

Abstract

backgroundCardiovascular disease (CVD) is the leading cause of death in women, responsible for approximately a third of all female deaths. Pregnancy complications are known to be associated with a greater risk of incident CVD in mothers. However, the relationships between pregnancy loss due to miscarriage, stillbirth, or therapeutic abortion, and future maternal cardiovascular health are under-researched. This study seeks to provide an up-to-date systematic review and meta-analysis of the relationship between these three forms of pregnancy loss and the subsequent development of CVD.

methodsThis systematic review will follow the Preferred Reporting Items for Systematic Review and Meta-Analysis checklist (PRISMA) and the Meta-analyses Of Observational Studies in Epidemiology (MOOSE) Checklist. A systematic search will be undertaken using publications identified in MEDLINE (PubMed), Scopus, Web of Knowledge, the CINAHL Nursing Database, and the Cochrane Library. The eligibility of each publication will be determined by predefined selection criteria. The quality of the included studies will be rated using the Newcastle-Ottawa Scale. Pooled measures of association will be computed using random-effects model meta-analyses. Between-study heterogeneity will be assessed using the I DISCUSSION: The results of this systematic review will discuss the long-term risks of multiple types of cardiovascular disease in women who have experienced miscarriage, stillbirth, and/or therapeutic abortion. It will contribute to the growing field of cardio-obstetrics as the first to consider the full breadth of literature regarding the association between all forms of pregnancy loss and future maternal cardiovascular disease. SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration number [CRD42020167587].

Indexed as

Abortion, InducedAbortion, SpontaneousCardiovascular DiseasesAbortion, TherapeuticFemaleHumansMeta-Analysis as TopicObservational Studies as TopicPregnancyStillbirthSystematic Reviews as TopicAbortionCardiovascular diseaseCoronary heart diseaseMeta-analysisMiscarriageProtocolStillbirthStrokeSystematic review

Identifiers

PMID33028393
PMCPMC7542880
OpenAlexW3091914509

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.