ArticleRadiation oncology (London, England)2020
Feasibility study: spot-scanning proton arc therapy (SPArc) for left-sided whole breast radiotherapy.
Article in Radiation oncology (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 55 citations in OpenAlex.
- Develop a novel non-coplanar trajectory optimization algorithm for an efficient 4pi spot-scanning proton Arc (SPArcMedical physics · 2026Article
- Particle Arc Therapy in Cancer Radiotherapy: A Scoping Review of Feasibility and Dosimetric Evidence.Cancers · 2026Review
- Mid-range arc therapy for efficient and RBE-robust proton treatment.Physics in medicine and biology · 2026Article
- Advancing proton therapy: Dosimetric superiority of proton arc therapy over IMPT in esophageal cancer treatment.Journal of applied clinical medical physics · 2026Article
- Treatment planning comparison of proton arc therapy and intensity modulated proton therapy for synchronous bilateral breast or chest wall and regional nodal irradiation.Physics and imaging in radiation oncology · 2026Article
- Reduced beam time and distal linear energy transfer with mini-ridge filters in pencil beam scanning proton therapy.Physics and imaging in radiation oncology · 2026Article
- A study on the application of range shifter and bolus in spot-scanning proton arc (SPArc) therapy after modified radical mastectomy for left-sided breast cancer.Frontiers in public health · 2026Article
- Proton arc therapy and associated improvements in quality-adjusted life expectancy for head-and-neck cancer patients compared to volumetric modulated arc therapy and intensity-modulated proton therapy.Physics in medicine and biology · 2025Article
- Upright positioning enhances beam angle optimization and organ sparing in head and neck carbon-ion radiotherapy with fixed-beam systems.Radiation oncology (London, England) · 2025Article
- Automated Planning for Bias-Free Validation of Discrete Proton Arc Therapy for Oropharyngeal Cancer.International journal of particle therapy · 2025Article
- Dynamic proton arc treatment planning study for oesophageal cancer.Physics and imaging in radiation oncology · 2025Article
- A novel adaptive energy switching algorithm for proton arc therapy based on the machine-specific delivery characteristics.Medical physics · 2025Article
- Development and dosimetric verification of static SHArc: Step-and-shoot carbon ion arc therapy for LETMedical physics · 2025Article
- Investigate gantry position error effect on dynamic spot-scanning proton arc (SPArc) therapy.Physics in medicine and biology · 2025Article
- Shoot-through layers in upright proton arcs unlock advantages in plan quality and range verification.Medical physics · 2025Article
- First Clinical Implementation of Step-and-Shoot Proton Arc Therapy for Head and Neck Cancer Treatment.International journal of particle therapy · 2025Article
- Feasibility of Utilizing Spot-Scanning Proton Arc (SPArc) for Whole-Lung Irradiation: A Case Report.International journal of particle therapy · 2025Article
- Gantry-based pencil beam scanning proton therapy for uveal melanoma: IMPT versus proton arc therapy.Radiation oncology (London, England) · 2025Article
- Partial and full arc with DynamicARC technique in pencil beam scanning proton therapy for bilateral head and neck cancer: A feasibility and dosimetric study.Journal of applied clinical medical physics · 2025Article
- Explore the feasibility of using spot-scanning proton arc therapy for a synchrotron accelerator-based proton therapy system - A simulation study.Journal of applied clinical medical physics · 2025Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study investigated the feasibility and potential clinical benefit of utilizing a new proton treatment technique: Spot-scanning proton arc (SPArc) therapy for left-sided whole breast radiotherapy (WBRT) to further reduce radiation dose to healthy tissue and mitigate the probability of normal tissue complications compared to conventional intensity modulated proton therapy (IMPT).
methodsEight patients diagnosed with left-sided breast cancer and treated with breast-preserving surgery followed by whole breast irradiation without regional nodal irradiation were included in this retrospective planning. Two proton treatment plans were generated for each patient: vertical intensity-modulated proton therapy used for clinical treatment (vIMPT, gantry angle 10°-30°) and SPArc for comparison purpose. Both SPArc and vIMPT plans were optimized using the robust optimization of ± 3.5% range and 5 mm setup uncertainties. Root-mean-square deviation dose (RMSD) volume histograms were used for plan robustness evaluation. All dosimetric results were evaluated based on dose-volume histograms (DVH), and the interplay effect was evaluated based on the accumulation of single-fraction 4D dynamic dose on CT50. The treatment beam delivery time was simulated based on a gantry rotation with energy-layer-switching-time (ELST) from 0.2 to 5 s.
resultsThe average D1 to the heart and LAD were reduced to 53.63 cGy and 82.25 cGy compared with vIMPT 110.38 cGy (p = 0.001) and 170.38 cGy (p = 0.001), respectively. The average V5Gy and V20Gy of ipsilateral lung was reduced to 16.77% and 3.07% compared to vIMPT 25.56% (p = 0.001) and 4.68% (p = 0.003). Skin3mm mean and maximum dose were reduced to 3999.38 cGy and 4395.63 cGy compared to vIMPT 4104.25 cGy (p = 0.039) and 4411.63 cGy (p = 0.043), respectively. A significant relative risk reduction (RNTCP = NTCP
conclusionSPArc technique can further reduce dose delivered to OARs and the probability of normal tissue complications in patients treated for left-sided WBRT.
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