SynthesisBMC biology2020
Effects of immune challenge on expression of life-history and immune trait expression in sexually reproducing metazoans-a meta-analysis.
Synthesis in BMC biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Effects of immune challenge on expression of life-history and immune trait expression in sexually reproducing metazoans-a meta-analysis.BMC biology · 2020Pooled it
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- Reciprocal costs of infection and reproduction inBiology letters · 2025Article
- Genetic Variation in Trophic Avoidance Behaviour Shows Fruit Flies are Generally Attracted to Bacterial Substrates.Ecology and evolution · 2024Article
- Non-invasive assessment of hormonal fluctuations during pregnancy in guanacos (Conservation physiology · 2024Article
- The shelterin protein expansion of telomere dynamics: Linking early life adversity, life history, and the hallmarks of aging.Neuroscience and biobehavioral reviews · 2023Review
- Evolutionary gain and loss of a pathological immune response to parasitism.Science (New York, N.Y.) · 2022Article
- Decomposing virulence to understand bacterial clearance in persistent infections.Nature communications · 2022Article
- No evidence of metabolic costs following adaptive immune activation or reactivation in house sparrows.Biology letters · 2022Article
- Sexual dimorphism in immune function and oxidative physiology across birds: The role of sexual selection.Ecology letters · 2022Article
- Experimental immune challenges reduce the quality of male antennae and female pheromone output.Scientific reports · 2022Article
- Female-limited X chromosome evolution reveals that lifespan is mainly modulated by interlocus rather than intralocus sexual conflict.Behavioral ecology and sociobiology · 2022Article
- Transcriptomic evidence for a trade-off between germline proliferation and immunity inEvolution letters · 2021Article
- Evolution of pathogen tolerance and emerging infections: A missing experimental paradigm.eLife · 2021Review
- Sexual conflict drives micro- and macroevolution of sexual dimorphism in immunity.BMC biology · 2021Article
- Seasonal variation in sex-specific immunity in wild birds.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundLife-history theory predicts a trade-off between investment into immune defence and other fitness-related traits. Accordingly, individuals are expected to upregulate their immune response when subjected to immune challenge. However, this is predicted to come at the expense of investment into a range of other traits that are costly to maintain, such as growth, reproduction and survival. Currently, it remains unclear whether the magnitude of such costs, and trade-offs involving immune investment and other traits, manifests consistently across species and sexes. To address this, we conducted a meta-analysis to investigate how changes in sex, ontogenetic stage and environmental factors shape phenotypic trait expression following an immune challenge.
resultsWe explored the effects of immune challenge on three types of traits across sexually reproducing metazoans: life-history, morphological and proximate immune traits (235 effect sizes, 53 studies, 37 species [21 invertebrates vs. 16 vertebrates]). We report a general negative effect of immune challenge on survival and reproduction, a positive effect on immune trait expression, but no effect on morphology or development time. The negative effects of immune challenge on reproductive traits and survival were larger in females than males. We also report a pronounced effect of the immune treatment agent used (e.g. whether the treatment involved a live pathogen or not) on the host response to immune challenge, and find an effect of mating status on the host response in invertebrates.
conclusionThese results suggest that costs associated with immune deployment following an immune challenge are context-dependent and differ consistently in their magnitude across the sexes of diverse taxonomic lineages. We synthesise and discuss the outcomes in the context of evolutionary theory on sex differences in life-history and highlight the need for future studies to carefully consider the design of experiments aimed at disentangling the costs of immune deployment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.