Evidence map›Paper›PMID 33028221›Full record

ArticleBMC cardiovascular disorders2020

Neuropsychological outcome after cardiac arrest: a prospective case control sub-study of the Targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest trial (TTM2).

Erik Blennow Nordström, Gisela Lilja, Susanna Vestberg, Susann Ullén, Hans Friberg, Niklas Nielsen, Katarina Heimburg, Lars Evald, Marco Mion, Magnus Segerström and 9 more

Registry-linked trialAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03543371 (Neuropsychological Outcome After Cardiac Arrest), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03543371 completednot on this map

Neuropsychological Outcome After Cardiac Arrest: A Prospective Case Control Sub-study of the Targeted Hypothermia Versus Targeted Normothermia After out-of Hospital Cardiac Arrest Trial (TTM2)

TypeobservationalSponsorRegion SkaneRan2018 to 2022Enrolled200ConditionsHeart Arrest, Out-Of-Hospital, Hypoxia-Ischemia, Brain, Cognition Disorders, Psychological DistressArmsNeuropsychological assessment
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Erik Blennow NordströmLund University, Skane University Hospital, Center for Cardiac Arrest at Lund University, Neurology Research Unit, Department of Clinical Sciences Lund, Neurology, Remissgatan 4, 221 85, Lund, Sweden. erik.blennow_nordstrom@med.lu.se.ORCID 0000-0003-1117-4412
Gisela LiljaLund University, Skane University Hospital, Center for Cardiac Arrest at Lund University, Neurology Research Unit, Department of Clinical Sciences Lund, Neurology, Remissgatan 4, 221 85, Lund, Sweden.
Susanna VestbergLund University, Department of Psychology, Lund, Sweden.
Susann UllénSkane University Hospital, Clinical Studies Sweden - Forum South, Lund, Sweden.
Hans FribergLund University, Skane University Hospital, Department of Clinical Sciences Lund, Intensive and Perioperative Care, Malmö, Sweden.
Niklas NielsenLund University, Helsingborg Hospital, Department of Clinical Sciences Lund, Anesthesiology and Intensive Care, Lund, Sweden.
Katarina HeimburgLund University, Skane University Hospital, Center for Cardiac Arrest at Lund University, Neurology Research Unit, Department of Clinical Sciences Lund, Neurology, Remissgatan 4, 221 85, Lund, Sweden.
Lars EvaldHammel Neurorehabilitation and Research Centre, Hammel, Denmark.
Marco MionEssex Cardiothoracic Centre, Basildon and Thurrock University Hospitals, Basildon, UK.
Magnus SegerströmSahlgrenska University Hospital, Department of Neurology and Department of Cardiology, Gothenburg, Sweden.
Anders M GrejsAarhus University Hospital and Aarhus University, Research Centre for Emergency Medicine, Emergency Department and Department of Clinical Medicine, Aarhus, Denmark.
Thomas KeebleEssex Cardiothoracic Centre, Basildon and Thurrock University Hospitals, Basildon, UK.
Hans KirkegaardAarhus University Hospital and Aarhus University, Research Centre for Emergency Medicine, Emergency Department and Department of Clinical Medicine, Aarhus, Denmark.
Hanna LjungLund University, Skane University Hospital, Center for Cardiac Arrest at Lund University, Neurology Research Unit, Department of Clinical Sciences Lund, Neurology, Remissgatan 4, 221 85, Lund, Sweden.
Sofia RoseClinical Psychology, Cardiff and Vale University Health Board, NHS Wales, Cardiff, UK.
Matthew P WiseCardiff University School of Medicine, Cardiff, UK.
Christian RylanderSahlgrenska Academy, University of Gothenburg, Institute of Clinical Sciences, Department of Anaesthesiology and Intensive Care Medicine, Gothenburg, Sweden.
Johan UndénLund University, Skane University Hospital, Department of Clinical Sciences Malmö, Anaesthesiology and Intensive Care Medicine, Lund, Sweden.
Tobias CronbergLund University, Skane University Hospital, Center for Cardiac Arrest at Lund University, Neurology Research Unit, Department of Clinical Sciences Lund, Neurology, Remissgatan 4, 221 85, Lund, Sweden.

Funding

Royal Swedish Academy of Sciences 2016-00428_5Skånes universitetssjukhus 2019-o000032
6 · The paper itself

Abstract

backgroundThis study is designed to provide detailed knowledge on cognitive impairment after out-of-hospital cardiac arrest (OHCA) and its relation to associated factors, and to validate the neurocognitive screening of the Targeted Hypothermia versus Targeted Normothermia after Out-of-Hospital Cardiac Arrest trial (TTM2-trial), assessing effectiveness of targeted temperature management after OHCA.

methodsThis longitudinal multi-center clinical study is a sub-study of the TTM2-trial, in which a comprehensive neuropsychological examination is performed in addition to the main TTM2-trial neurocognitive screening. Approximately 7 and 24 months after OHCA, survivors at selected study sites are invited to a standardized assessment, including performance-based tests of cognition and questionnaires of emotional problems, fatigue, executive function and insomnia. At 1:1 ratio, a matched control group from a cohort of acute myocardial infarction (MI) patients is recruited to perform the same assessment. We aim to include 100 patients per group. Potential differences between the OHCA patients and the MI controls at 7 and 24 months will be analyzed with a linear regression, using composite z-scores per cognitive domain (verbal, visual/constructive, working memory, episodic memory, processing speed, executive functions) as primary outcome measures. Results from OHCA survivors on the main TTM2-trial neurocognitive screening battery will be compared with neuropsychological test results at 7 months, using sensitivity and specificity analyses. DISCUSSION: In this study we collect detailed information on cognitive impairment after OHCA and compare this to a control group of patients with acute MI. The validation of the TTM2 neurocognitive screening battery could justify its inclusion in routine follow-up. Our results may have a potential to impact on the design of future follow-up strategies and interventions after OHCA.

trial registrationClinicalTrials.gov, NCT03543371 . Registered 1 June 2018.

Indexed as

CognitionHypothermia, InducedClinical Trials as TopicCognitive DysfunctionEuropeExecutive FunctionFemaleHumansLongitudinal StudiesMaleMemoryNeuropsychological TestsOut-of-Hospital Cardiac ArrestProspective StudiesResearch DesignTime FactorsCardiac arrestCognitive dysfunctionCognitive screeningNeuropsychological testsOutcome

Identifiers

PMID33028221
PMCPMC7542852

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.