Evidence map›Paper›PMID 33028107›Full record

ArticleCell transplantation

Transplantation of Adipose-Derived Stem Cells Alleviates Striatal Degeneration in a Transgenic Mouse Model for Multiple System Atrophy.

Christine Chang, Jen-Wei Liu, Bo Cheng Chen, Zhe Sheng Jiang, Chi Tang Tu, Che Hung Su, Hsin Han Yang, Zong Qi Liu, Yu Chen Deng, Chih Yu Chen and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Christine ChangDepartment of Life Science and Graduate Institute of Biotechnology, 63373National Dong Hwa University, Hualien, Taiwan, R.O.C.ORCID 0000-0001-8290-8458
Jen-Wei LiuDepartment of Life Science and Graduate Institute of Biotechnology, 63373National Dong Hwa University, Hualien, Taiwan, R.O.C.
Bo Cheng ChenDepartment of Life Science and Graduate Institute of Biotechnology, 63373National Dong Hwa University, Hualien, Taiwan, R.O.C.
Zhe Sheng JiangDepartment of Life Science and Graduate Institute of Biotechnology, 63373National Dong Hwa University, Hualien, Taiwan, R.O.C.
Chi Tang TuTaiwan Mitochondrion Applied Technology Co., Ltd., Hsinchu, Taiwan, R.O.C.
Che Hung SuDepartment of Life Science and Graduate Institute of Biotechnology, 63373National Dong Hwa University, Hualien, Taiwan, R.O.C.
Hsin Han YangDepartment of Life Science and Graduate Institute of Biotechnology, 63373National Dong Hwa University, Hualien, Taiwan, R.O.C.
Zong Qi LiuDepartment of Life Science and Graduate Institute of Biotechnology, 63373National Dong Hwa University, Hualien, Taiwan, R.O.C.
Yu Chen DengDepartment of Life Science and Graduate Institute of Biotechnology, 63373National Dong Hwa University, Hualien, Taiwan, R.O.C.
Chih Yu ChenDepartment of Life Science and Graduate Institute of Biotechnology, 63373National Dong Hwa University, Hualien, Taiwan, R.O.C.
Sheng-Tzung TsaiDepartment of Neurosurgery, Buddhist Tzu Chi General Hospital, Hualien, Taiwan, R.O.C.ORCID 0000-0001-6611-9440
Shinn Zong LinDepartment of Neurosurgery, Buddhist Tzu Chi General Hospital, Hualien, Taiwan, R.O.C.
Tzyy-Wen ChiouDepartment of Life Science and Graduate Institute of Biotechnology, 63373National Dong Hwa University, Hualien, Taiwan, R.O.C.
National Dong Hwa University · TWBuddhist Tzu Chi General Hospital · TWTzu Chi University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with multiple system atrophy (MSA), a progressive neurodegenerative disorder of adult onset, were found less than 9 years of life expectancy after onset. The disorders include bradykinesia and rigidity commonly seen in Parkinsonism disease and additional signs such as autonomic dysfunction, ataxia, or dementia. In clinical treatments, MSA poorly responds to levodopa, the drug used to remedy Parkinsonism disease. The exact cause of MSA is still unknown, and exploring a therapeutic solution to MSA remains critical. A transgenic mouse model was established to study the feasibility of human adipose-derived stem cell (ADSC) therapy in vivo. The human ADSCs were transplanted into the striatum of transgenic mice via intracerebral injection. As compared with sham control, we reported significantly enhanced rotarod performance of transgenic mice treated with ADSC at an effective dose, 2 × 10

Indexed as

Adipose Tissuealpha-SynucleinAnimalsApoptosisCell TrackingCorpus StriatumDisease Models, AnimalGlial Cell Line-Derived Neurotrophic FactorHumansMice, TransgenicModels, BiologicalMultiple System AtrophyMyelin Basic ProteinNerve DegenerationPromoter Regions, GeneticProtein Aggregatesalpha-SynucleinGlial Cell Line-Derived Neurotrophic FactorMyelin Basic ProteinProtein AggregatesADSCapoptosisautophagyGDNFMSAtransgenic mouseα-synuclein

Identifiers

PMID33028107
PMCPMC7784590
OpenAlexW3092006907

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.