Evidence map›Paper›PMID 33028070›Full record

ArticleThe Korean journal of internal medicine2021

Effect of urinary angiotensinogen and high-salt diet on blood pressure in patients with chronic kidney disease: results from the Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease (KNOW-CKD).

Ha Yeon Kim, Hong Sang Choi, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Su-Ah Sung, Seung Hyeok Han, Kook-Hwan Oh, Curie Ahn, Soo Wan Kim

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Korean journal of internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Ha Yeon KimDepartment of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
Hong Sang ChoiDepartment of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
Chang Seong KimDepartment of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
Eun Hui BaeDepartment of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
Seong Kwon MaDepartment of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
Su-Ah SungDepartment of Internal Medicine, Nowon Eulji Medical Center, Eulji University, Seoul, Korea.
Seung Hyeok HanDepartment of Internal Medicine and Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, Korea.
Kook-Hwan OhDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Curie AhnDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Soo Wan KimDepartment of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
Chonnam National University · KRSeoul National University · KREulji University · KRYonsei University · KR

Funding

Chonnam National University Hospital Biomedical Research Institute BCR18015-1Korea Centers for Disease Control and Prevention 2011E3300300Korea Centers for Disease Control and Prevention 2012E3301100Korea Centers for Disease Control and Prevention 2013E3301600Korea Centers for Disease Control and Prevention 2013E3301601Korea Centers for Disease Control and Prevention 2013E3301602Korea Centers for Disease Control and Prevention 2016E3300200Ministry of Science and ICT 2017M3A9E8023001Ministry of Science, ICT and Future Planning 2015R1D1A1A01061037National Research Foundation of Korea
6 · The paper itself

Abstract

BACKGROUND/

aimsThis study aimed to investigate whether urinary angiotensinogen (UAGT) excretion was associated with elevated blood pressure in patients with chronic kidney disease (CKD) and to evaluate the relationship among blood pressure, intra-renal renin-angiotensin system (RAS) activity, and dietary sodium in patients with CKD.

methodsParticipants from the Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease (KNOW-CKD) were included. Of the total cohort of 2,238 individuals with CKD, we included 1,955 participants who underwent complete 24-hour urinary sodium (24-hour UNa) analysis. They were categorized into three groups according to three tertiles of their 24-hour UNa, reflecting daily salt intake. To measure intra-renal RAS activity, the UAGT excretion was assayed with an enzyme-linked immunosorbent assay.

resultsElevated 24-hour UNa levels, logarithm of UAGT-to-creatinine ratio (UAGT/Cr), increased waist-to-hip ratio, and decreased estimated glomerular filtration rate were the risk factors for increased systolic blood pressure. Systolic blood pressure showed a positive correlation with 24-hour UNa levels and logarithm of UAGT/Cr.

conclusionUAGT and urinary sodium excretion are independent determinants of systolic blood pressure in patients with CKD. These findings suggest that increased systolic blood pressure in CKD patients is associated with both increased dietary sodium levels and intra-renal RAS activity. The risk of elevated systolic blood pressure in the 3rd tertile of both the UAGT/Cr and 24-hour UNa groups was about 2.3 times higher than that in the reference group.

Indexed as

AngiotensinogenRenal Insufficiency, ChronicBlood PressureCohort StudiesDietHumansKidneyRenin-Angiotensin SystemRepublic of KoreaSodium Chloride, DietaryAngiotensinogenSodium Chloride, Dietary24-Hour urine-sodium excretionChronic kidney diseaseHypertensionUrine angiotensinogen

Identifiers

PMID33028070
PMCPMC8137406
OpenAlexW3092058676

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.