Evidence map›Paper›PMID 33027949›Full record

ArticleAnimals : an open access journal from MDPI2020

Immune Response in Young Thoroughbred Racehorses under Training.

Katia Cappelli, Massimo Amadori, Samanta Mecocci, Arianna Miglio, Maria Teresa Antognoni, Elisabetta Razzuoli

Abstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Equine MicroRNAs: Performance, Reproduction, and Disease.MicroRNA (Shariqah, United Arab Emirates) · 2026
    Review
  2. Immunology of Physical Exercise: IsInternational journal of molecular sciences · 2024
    Review
  3. Effect of Regular Training on Platelet Function in Untrained Thoroughbreds.Animals : an open access journal from MDPI · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Immune Functions Alterations Due to Racing Stress in Thoroughbred Horses.Animals : an open access journal from MDPI · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Katia CappelliDipartimento di Medicina Veterinaria, Universià degli Studi di Perugia, 06126 Perugia, Italy.ORCID 0000-0002-3141-771X
Massimo AmadoriRete Nazionale di Immunologia Veterinaria (Italian Society of Veterinary Immunology), via Istria, 3, 25125 Brescia, Italy.ORCID 0000-0002-7562-0322
Samanta MecocciDipartimento di Medicina Veterinaria, Universià degli Studi di Perugia, 06126 Perugia, Italy.ORCID 0000-0003-2998-0412
Arianna MiglioDipartimento di Medicina Veterinaria, Universià degli Studi di Perugia, 06126 Perugia, Italy.ORCID 0000-0002-5459-6298
Maria Teresa AntognoniDipartimento di Medicina Veterinaria, Universià degli Studi di Perugia, 06126 Perugia, Italy.
Elisabetta RazzuoliNational Reference Center of Veterinary and Comparative Oncology (CEROVEC), Piazza Borgo Pila 39/24, 16129 Genoa, Italy.ORCID 0000-0002-6597-475X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Training has a great impact on the physiology of an athlete and, like all stressful stimuli, can trigger an innate immune response and inflammation, which is part of a wider coping strategy of the host to restore homeostasis. The Thoroughbred racehorse is a valid animal model to investigate these changes thanks to its homogeneous training and highly selected genetic background. The aim of this study was to investigate modifications of the innate immune response and inflammation in young untrained Thoroughbred racehorses during the first training season through haematological and molecular investigations. Twenty-nine Thoroughbred racehorses were followed during their incremental 3-month sprint exercise schedule. Blood collection was performed at time 0 (T0; before starting the intense training period), 30 days after T0 (T30), and 90 days after T0 (T90). Haematological parameters (red and white blood cells, haemoglobin, and platelets) were evaluated and haematocrit (HCT), mean corpuscular haemoglobin concentration (MCHC), and red cells width distribution + standard deviation (RDW-SD) were calculated. Moreover, via RT-qPCR, we investigated the expression of, Interleukin

Indexed as

cytokinesimmune responseintense trainingstressthoroughbred racehorse

Identifiers

PMID33027949
PMCPMC7600081

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.