Evidence map›Paper›PMID 33027906›Full record

ReviewInternational journal of molecular sciences2020

Calmodulin Binding Proteins and Alzheimer's Disease: Biomarkers, Regulatory Enzymes and Receptors That Are Regulated by Calmodulin.

Danton H O'Day

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 54 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Danton H O'DayCell and Systems Biology, University of Toronto, Toronto, ON M5S 3G5, Canada.ORCID 0000-0003-0163-9044
University of Toronto · CA

Funding

Natural Sciences and Engineering Research Council of Canada A6057
6 · The paper itself

Abstract

The integral role of calmodulin in the amyloid pathway and neurofibrillary tangle formation in Alzheimer's disease was first established leading to the "Calmodulin Hypothesis". Continued research has extended our insight into the central function of the small calcium sensor and effector calmodulin and its target proteins in a multitude of other events associated with the onset and progression of this devastating neurodegenerative disease. Calmodulin's involvement in the contrasting roles of calcium/CaM-dependent kinase II (CaMKII) and calcineurin (CaN) in long term potentiation and depression, respectively, and memory impairment and neurodegeneration are updated. The functions of the proposed neuronal biomarker neurogranin, a calmodulin binding protein also involved in long term potentiation and depression, is detailed. In addition, new discoveries into calmodulin's role in regulating glutamate receptors (mGluR, NMDAR) are overviewed. The interplay between calmodulin and amyloid beta in the regulation of PMCA and ryanodine receptors are prime examples of how the buildup of classic biomarkers can underly the signs and symptoms of Alzheimer's. The role of calmodulin in the function of stromal interaction molecule 2 (STIM2) and adenosine A2A receptor, two other proteins linked to neurodegenerative events, is discussed. Prior to concluding, an analysis of how targeting calmodulin and its binding proteins are viable routes for Alzheimer's therapy is presented. In total, calmodulin and its binding proteins are further revealed to be central to the onset and progression of Alzheimer's disease.

Indexed as

Alzheimer DiseaseCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium SignalingCalmodulinCalmodulin-Binding ProteinsHumansNeurograninNeuronsReceptor, Adenosine A2AReceptors, GlutamateStromal Interaction Molecule 2CalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2CalmodulinCalmodulin-Binding ProteinsNeurograninReceptor, Adenosine A2AReceptors, GlutamateStromal Interaction Molecule 2adenosine receptorAlzheimer’s diseasebiomarkerscalcium hypothesiscalmodulin binding proteinsglutamate receptorsneurodegenerationneurograninPMCAryanodine receptor

Identifiers

PMID33027906
PMCPMC7582761
OpenAlexW3091350622

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.