ArticleCurrent protocols in immunology2020
Inducing Experimental Polymicrobial Sepsis by Cecal Ligation and Puncture.
Article in Current protocols in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 46 citations in OpenAlex.
- Adenosine 5'-monophosphate prevents sepsis-associated muscle wasting by activating AMPK and suppressing IL-1β inflammatory cytokines.Journal of intensive care · 2026Article
- Different Functions of Human Scavenger Receptors BI and BII Overexpressed in a Murine Abdominal Sepsis Model.Biomolecules · 2026Article
- Secreted phospholipase PLA2G5 acts as a hemolytic factor in sepsis.The Journal of clinical investigation · 2026Article
- Anti-Inflammatory and Anti-Oxidant Effects ofBiomedicines · 2026Article
- Hydrogen gas (HFrontiers in immunology · 2026Article
- T cell immunometabolic dysfunction in a mouse model of cecal ligation and puncture-induced sepsis.BMC immunology · 2025Article
- Precision Profiling of Disease Progression in Murine Models of Sepsis and Septic Shock.International journal of molecular sciences · 2025Article
- Cannabinoids in preclinical research of sepsis: a scoping review.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Article
- Endotoxin-induced m6A RNA methylation landscape in lung endothelial cells: role of METTL3 in regulating inflammation and injury during acute lung injury.Biochimica et biophysica acta. Molecular basis of disease · 2025Article
- PD-L1Nature communications · 2025Article
- The Effect of Ozone on Kidney and Liver Tissues in the Treatment of Sepsis Caused by Cecal Perforation in Diabetic Mice.Drug design, development and therapy · 2025Article
- Sepsis prevents the development of experimental type 1 diabetes.Frontiers in immunology · 2025Article
- Immunomodulatory Effects and Protection in Sepsis by the Antibiotic Moxifloxacin.Antibiotics (Basel, Switzerland) · 2024Article
- Metabolic reprogramming and dysregulated IL-17 production impairs CD4 T cell function post sepsis.iScience · 2024Article
- Evaluation of the efficacy of silymarin and dexmedetomidine on kidney and lung tissue in the treatment of sepsis in rats with cecal perforation.Experimental and therapeutic medicine · 2024Article
- Mouse Models of Sepsis.Current protocols · 2024Article
- Defining Parameters That Modulate Susceptibility and Protection to Respiratory Murine Coronavirus MHV1 Infection.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- A pairwise cytokine code explains the organism-wide response to sepsis.Nature immunology · 2024Article
- Septic macrophages induce T cells immunosuppression in a cell-cell contact manner with the involvement of CR3.Heliyon · 2024Article
- Brevilin A ameliorates sepsis-induced cardiomyopathy through inhibiting NLRP3 inflammation.Annals of medicine and surgery (2012) · 2023Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Numerous models are available for the preclinical study of sepsis, and they fall into one of three general categories: (1) administration of exogenous toxins (e.g., lipopolysaccharide, zymosan), (2) virulent bacterial or viral challenge, and (3) host barrier disruption, e.g., cecal ligation and puncture (CLP) or colon ascendens stent peritonitis (CASP). Of the murine models used to study the pathophysiology of sepsis, CLP combines tissue necrosis and polymicrobial sepsis secondary to autologous fecal leakage, as well as hemodynamic and biochemical responses similar to those seen in septic humans. Further, a transient numerical reduction of multiple immune cell types, followed by development of prolonged immunoparalysis, occurs in CLP-induced sepsis just as in humans. Use of the CLP model has led to a vast expansion in knowledge regarding the intricate physiological and cellular changes that occur during and after a septic event. This updated article details the steps necessary to perform this survival surgical technique, as well as some of the obstacles that may arise when evaluating the sepsis-induced changes within the immune system. It also provides representative monoclonal antibody (mAb) panels for multiparameter flow cytometric analysis of the murine immune system in the septic host. © 2020 Wiley Periodicals LLC. Basic Protocol: Cecal ligation and puncture in the mouse.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.