ArticleNeonatology2020
Pharmacoepidemiology of Furosemide in the Neonatal Intensive Care Unit.
Article in Neonatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Furosemide Safety in Preterm Infants at Risk for Bronchopulmonary Dysplasia: A Randomized Clinical Trial.The Journal of pediatrics · 2025Trial
- Severe, late-onset neutropenia associated with prolonged furosemide administration in an extremely preterm infant: a case report and literature review.BMC pediatrics · 2026Review
- Furosemide-Induced Nephrocalcinosis in Premature Neonates: A Critical Review of Observational Data.Children (Basel, Switzerland) · 2025Review
- Use of furosemide in preterm neonates with acute kidney injury is associated with increased mortality: results from the TINKER registry.Pediatric nephrology (Berlin, Germany) · 2024Article
- Off-label use of drugs in pediatrics: a scoping review.European journal of pediatrics · 2022Article
- Association between postmenstrual age and furosemide dosing practices in very preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2022Observational
- Cumulative Doses Predict the Risk of Furosemide-Induced Electrolyte Abnormalities in Critically Ill Neonates.Therapeutics and clinical risk management · 2022Article
- Pharmacoepidemiology of Drug Exposure in Intubated and Non-Intubated Preterm Infants With Severe Bronchopulmonary Dysplasia.Frontiers in pharmacology · 2021Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundFurosemide is commonly used off-label in the neonatal intensive care unit (NICU), but current dosing practices vary widely.
objectivesTo describe dosing practices including route, dose, and duration of exposure to furosemide in a large number of community and tertiary NICUs across North America.
methodUsing the Pediatrix Medical Group Clinical Data Warehouse, we identified infants who received ≥1 dose of furosemide between 1997 and 2016. We excluded infants with incomplete dosing data. We calculated average daily furosemide dose, cumulative dose, total days of exposure, and maximum daily dose. We compared dosing between infants born at <32 weeks gestational age (GA) and ≥32 weeks GA.
resultsA total of 18,572 infants had complete dosing data. The median (interquartile value) postnatal age at first exposure was 11 days (4, 26), the median maximum daily dose was 1.0 mg/kg (0.97, 1.6), the median average daily dose was 1.0 mg/kg (0.88, 1.1), and the median cumulative dose was 2.0 mg/kg (1.0, 4.5). The median total duration of exposure was 2 days (1, 4). A total of 177 (1%) infants received ≥4 mg/kg/day of furosemide. Infants born <32 weeks GA were an older age at initial furosemide exposure compared to those born ≥32 weeks GA: 19 versus 4 days, p < 0.001.
conclusionsMost infants received short courses of furosemide within the labeled dosing parameters. Further studies are needed to assess the safety and efficacy of furosemide in the NICU.
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