Evidence map›Paper›PMID 33027776›Full record

ArticleJournal of breath research2020

The correlation between breath acetone and blood betahydroxybutyrate in individuals with type 1 diabetes.

Gus Hancock, Shrinivas Sharma, Martin Galpin, Daniel Lunn, Clare Megson, Rob Peverall, Graham Richmond, Grant A D Ritchie, Katharine R Owen

Registry-linked trialOpen access · hybridAbstract read
PubMed Publisher
In one paragraph

Article in Journal of breath research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05541484 (Ketone Monitoring in T1D), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05541484 phase4completedstarted 2022, after this paper: background citation

Ketone Monitoring in T1D: Effect of SGLT2i During Usual Care and With Insulin Deficiency

Ran2022Enrolled21Registered outcomes3Posted comparisons1ConditionsDiabetes Mellitus, Type 1ArmsBiosense Breath Ketone Analyzer, SGLT2 inhibitor
Open the trial in the graph
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Systematic comparison of methods for offline breath sampling.Analytical and bioanalytical chemistry · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Gus HancockDepartment of Chemistry, University of Oxford, Physical and Theoretical Chemistry Laboratory, South Parks Road, Oxford OX1 3QZ, United Kingdom.ORCID 0000-0003-1166-4104
Shrinivas SharmaOxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, United Kingdom.
Martin GalpinDepartment of Chemistry, University of Oxford, Physical and Theoretical Chemistry Laboratory, South Parks Road, Oxford OX1 3QZ, United Kingdom.
Daniel LunnDepartment of Statistics, University of Oxford, Oxford OX1 3TG, United Kingdom.
Clare MegsonOxford Children's Hospital, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom.
Rob PeverallDepartment of Chemistry, University of Oxford, Physical and Theoretical Chemistry Laboratory, South Parks Road, Oxford OX1 3QZ, United Kingdom.ORCID 0000-0003-2326-2495
Graham RichmondDepartment of Chemistry, University of Oxford, Physical and Theoretical Chemistry Laboratory, South Parks Road, Oxford OX1 3QZ, United Kingdom.
Grant A D RitchieDepartment of Chemistry, University of Oxford, Physical and Theoretical Chemistry Laboratory, South Parks Road, Oxford OX1 3QZ, United Kingdom.ORCID 0000-0003-1663-7770
Katharine R OwenOxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, United Kingdom.
University of Oxford · GBChurchill Hospital · GBJohn Radcliffe Hospital · GB

Funding

Department of Health
6 · The paper itself

Abstract

Ketone testing is an important element of the self-management of illness in type 1 diabetes. The aim of the present study was to see if a breath test for acetone could be used to predict quantitatively the levels of the ketone betahydroxybutyrate in the blood of those with type 1 diabetes, and thus be used as an alternative to capillary testing for ketones. Simultaneous capillary ketones and breath acetone were measured in 72 individuals with type 1 diabetes attending a diabetes clinic and on 9 individuals admitted to hospital with diabetic ketoacidosis. Capillary blood measurements ranged from 0.1 mmol l

Indexed as

3-Hydroxybutyric AcidAcetoneBreath TestsCapillariesDiabetes Mellitus, Type 1Diabetic KetoacidosisHumansKetonesModels, BiologicalReference ValuesRisk Factors3-Hydroxybutyric AcidAcetoneKetones

Identifiers

PMID33027776
OpenAlexW3091771906

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.