Evidence map›Paper›PMID 33027774›Full record

ArticleNanotechnology2021

Quantification of low affinity binding interactions between natural killer cell inhibitory receptors and targeting ligands with a self-induced back-action actuated nanopore electrophoresis (SANE) sensor.

Sai Santosh Sasank Peri, Manoj Kumar Sabnani, Muhammad Usman Raza, Elizabeth L Urquhart, Soroush Ghaffari, Jung Soo Lee, Min Jun Kim, Jon Weidanz, George Alexandrakis

Open access · greenAbstract read
In one paragraph

Article in Nanotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Localized Nanopore Fabrication via Controlled Breakdown.Nanomaterials (Basel, Switzerland) · 2022
    Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Sai Santosh Sasank PeriDepartment of Electrical Engineering, University of Texas at Arlington, Arlington, TX, United States of America.ORCID 0000-0002-7224-9433
Manoj Kumar SabnaniDepartment of Biology, University of Texas at Arlington, Arlington, TX, United States of America.
Muhammad Usman RazaDepartment of Electrical Engineering, University of Texas at Arlington, Arlington, TX, United States of America.ORCID 0000-0003-4276-5573
Elizabeth L UrquhartDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX, United States of America.
Soroush GhaffariDepartment of Biology, University of Texas at Arlington, Arlington, TX, United States of America.
Jung Soo LeeDepartment of Mechanical Engineering, Southern Methodist University, Dallas, TX, United States of America.
Min Jun KimDepartment of Mechanical Engineering, Southern Methodist University, Dallas, TX, United States of America.ORCID 0000-0002-0819-1644
Jon WeidanzDepartment of Biology, University of Texas at Arlington, Arlington, TX, United States of America.
George AlexandrakisDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX, United States of America.
The University of Texas at Arlington · USSouthern Methodist University · US

Funding

Interdisciplinary Training in Nanotechnology for Cardiovascular and Lung Diseases in North TexasT32HL134613 · NHLBI · UNIVERSITY OF TEXAS ARLINGTON · PI NGUYEN, KYTAI TRUONG · 2017 to 2021
$1.1M
Nanotechnology Enabled Selection of MHC-Peptide Ligands to Personalize Cancer TherapyR21CA240220 · NCI · UNIVERSITY OF TEXAS ARLINGTON · PI ALEXANDRAKIS, GEORGIOS · 2020 to 2021
$594k
NCI NIH HHS R21 CA240220NHLBI NIH HHS T32 HL134613
6 · The paper itself

Abstract

A plasmonic nanopore sensor enabling detection of bimodal optical and electrical molecular signatures was fabricated and tested for its ability to characterize low affinity ligand-receptor interactions. This plasmonic nanosensor uses self-induced back-action (SIBA) for optical trapping to enable SIBA-actuated nanopore electrophoresis (SANE) through a nanopore located immediately below the optical trap volume. A natural killer (NK) cell inhibitory receptor heterodimer molecule CD94/NKG2A was synthesized to target a specific peptide-presenting Qa-1

Indexed as

ElectrophoresisNanoporesReceptors, Natural Killer CellAnimalsKineticsLigandsMiceMice, Inbred C57BLPeptidesProtein BindingLigandsPeptidesReceptors, Natural Killer Cell

Identifiers

PMID33027774
PMCPMC8346883
OpenAlexW3091807510

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.