Evidence map›Paper›PMID 33027744›Full record

ArticleCell calcium2020

Preventing a shock to the system. Two-pore channel 1 negatively regulates anaphylaxis.

Sandip Patel, Karl-Johan Malmberg

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell calcium, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. TPC Functions in the Immune System.Handbook of experimental pharmacology · 2023
    Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 3 countries.

Sandip PatelDepartment of Cell and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK. Electronic address: patel.s@ucl.ac.uk.
Karl-Johan MalmbergInstitute of Clinical Medicine, University of Oslo, 0318, Oslo, Norway; Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, 0310, Oslo, Norway; Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, 14186, Stockholm, Sweden.
University College London · GBUniversity of Oslo · NO

Funding

Parkinson's UK H-1202
6 · The paper itself

Abstract

The mammalian two-pore channels TPC1 and TPC2 are patho-physiologically relevant endo-lysosomal cation channels regulated by the Ca

Indexed as

AnaphylaxisCalcium ChannelsAnimalsCalciumLysosomesMast CellsMiceNADPCalciumCalcium ChannelsNADPMast cellsNAADPSecretionTPC1

Identifiers

PMID33027744
OpenAlexW3088929262

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.