Evidence map›Paper›PMID 33027689›Full record

ArticleStructure (London, England : 1993)2020

A Designer Quest for the Achilles' Heel of Influenza.

J Eduardo Fajardo, Andras Fiser

Abstract readComment
In one paragraph

Article in Structure (London, England : 1993), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

J Eduardo FajardoDepartment of Systems and Computational Biology, Albert Einstein College of Medicine, 1301 Morris Park Ave, Bronx, NY 10461, USA; Department of Biochemistry, Albert Einstein College of Medicine, 1301 Morris Park Ave, Bronx, NY 10461, USA.
Andras FiserDepartment of Systems and Computational Biology, Albert Einstein College of Medicine, 1301 Morris Park Ave, Bronx, NY 10461, USA; Department of Biochemistry, Albert Einstein College of Medicine, 1301 Morris Park Ave, Bronx, NY 10461, USA. Electronic address: andras.fiser@einsteinmed.org.

Funding

Molecular basis of recognition in the Immunological SynapseR35GM136357 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI FISER, ANDRAS · 2020 to 2024
$2.7M
Molecular basis of receptor-ligand recognition in the Immunological SynapseR01GM118709 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI FISER, ANDRAS · 2016 to 2019
$2.3M
Interdisciplinary protein engineering approach to design high affinity antibodies for flavivirusesR01AI141816 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI FISER, ANDRAS · 2019 to 2023
$2.1M
NIAID NIH HHS R01 AI141816NIGMS NIH HHS R01 GM118709NIGMS NIH HHS R35 GM136357
6 · The paper itself

Abstract

Monoclonal antibodies are attractive but, in certain applications, limited therapeutic modalities due to their large size and high specificity. In this issue of Structure, Sevy at al. describe a computationally designed cyclic peptide mimicking the CDRH3 loop of the C05 antibody against influenza showing the potential utility of designer biologics.

Indexed as

Influenza, HumanAntibodies, MonoclonalBiophysical PhenomenaHumansPeptides, CyclicAntibodies, MonoclonalPeptides, Cyclic

Identifiers

PMID33027689
PMCPMC8908349

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.