ArticleCell metabolism2020
Exposure to Static Magnetic and Electric Fields Treats Type 2 Diabetes.
Erratum issuedOpen access · bronzeAbstract read
In one paragraph
Article in Cell metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 38 papers.
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38citing papers in PubMed
13.6field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 81 citations in OpenAlex.
- Silent forces, hidden currents: the influence of static magnetic field stimulation on tumor biophysics.npj biomedical innovations · 2026Review
- The development and application of magnetic surgery in clinical treatment.Biomedical engineering online · 2026Review
- Transcranial microtesla magnetic fields suppress neuroinflammation and neuronal oxidative stress burden.iScience · 2026Article
- Investigating Cellular Magnetic Bioeffects Using Two-Channel, Two-Photon Autofluorescence Lifetime Microscopy.IEEE transactions on molecular, biological, and multi-scale communications · 2026Article
- Skeletal muscle reprogramming in peripheral nerve injury: mechanisms, therapeutic roles, and complication management.Experimental biology and medicine (Maywood, N.J.) · 2026Review
- Repetitive transcranial magnetic stimulation elicits weight loss and improved insulin sensitivity in type 2 diabetic rats.Animal models and experimental medicine · 2025Article
- Little strokes fell big oaks: The use of weak magnetic fields and reactive oxygen species to fight cancer.Redox biology · 2025Review
- Reactive oxygen species mediate bioeffects of static magnetic field via impairment of long-chain fatty acid degradation inFrontiers in microbiology · 2025Article
- Efficacy of exercise and electromagnetic field therapy on cardiovascular disease risk in patients with type 2 diabetes mellitus. Randomized controlled trial.American journal of cardiovascular disease · 2025Article
- Applying auricular magnetic therapy to decrease blood glucose levels and promote the healing of gangrene in diabetes patients: a case report.Journal of medical case reports · 2024Article
- Quantitative measurements of reactive oxygen species partitioning in electron transfer flavoenzyme magnetic field sensing.Frontiers in physiology · 2024Article
- Enhanced Effects of Intermittent Fasting by Magnetic Fields in Severe Diabetes.Research (Washington, D.C.) · 2024Article
- [Research advances in neuromodulation techniques for blood glucose regulation and diabetes intervention].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2023Article
- Magnetic Field Intervention Enhances Cellular Migration Rates in Biological Scaffolds.Bioengineering (Basel, Switzerland) · 2023Article
- Mitochondria- and NOX4-dependent antioxidant defense mitigates progression to nonalcoholic steatohepatitis in obesity.The Journal of clinical investigation · 2023Article
- Recent Developments in Metallic Degradable Micromotors for Biomedical and Environmental Remediation Applications.Nano-micro letters · 2023Review
- Static Magnetic Fields Promote Generation of Muscle Lineage Cells from Pluripotent Stem Cells and Myoblasts.Stem cell reviews and reports · 2023Article
- Improving Mitochondrial Function in Skeletal Muscle Contributes to the Amelioration of Insulin Resistance by Nicotinamide Riboside.International journal of molecular sciences · 2023Article
- Electromagnetic fields ameliorate hepatic lipid accumulation and oxidative stress: potential role of CaMKKβ/AMPK/SREBP-1c and Nrf2 pathways.Biomedical engineering online · 2023Article
- Applications of synthetic biology in medical and pharmaceutical fields.Signal transduction and targeted therapy · 2023Review
Corrections and comments
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Authors and funding
32 authors at 5 institutions in 1 country.
Calvin S CarterDepartment of Pediatrics and Division of Medical Genetics and Genomics, University of Iowa Hospitals & Clinics, Iowa City, IA, USA. Electronic address: calvin-carter@uiowa.edu.
Sunny C HuangDepartment of Pediatrics and Division of Medical Genetics and Genomics, University of Iowa Hospitals & Clinics, Iowa City, IA, USA; Medical Scientist Training Program, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Charles C SearbyDepartment of Pediatrics and Division of Medical Genetics and Genomics, University of Iowa Hospitals & Clinics, Iowa City, IA, USA.
Benjamin CassaidyDepartment of Pediatrics and Division of Medical Genetics and Genomics, University of Iowa Hospitals & Clinics, Iowa City, IA, USA.
Michael J MillerDepartment of Physics and Astronomy, University of Iowa, Iowa City, IA, USA.
Wojciech J GrzesikFraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Ted B PiorczynskiDepartment of Physiology and Developmental Biology, Brigham Young University, Provo, UT, USA.
Thomas K PakDepartment of Pediatrics and Division of Medical Genetics and Genomics, University of Iowa Hospitals & Clinics, Iowa City, IA, USA; Medical Scientist Training Program, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Susan A WalshDepartment of Radiology, Division of Nuclear Medicine, University of Iowa Hospitals & Clinics, Iowa City, IA, USA.
Michael AcevedoDepartment of Radiology, Division of Nuclear Medicine, University of Iowa Hospitals & Clinics, Iowa City, IA, USA.
Qihong ZhangDepartment of Pediatrics and Division of Medical Genetics and Genomics, University of Iowa Hospitals & Clinics, Iowa City, IA, USA.
Kranti A MapuskarFree Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa Hospitals & Clinics, Iowa City, IA, USA.
Ginger L MilneDepartment of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.
Antentor O HintonFraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Deng-Fu GuoDepartment of Neuroscience and Pharmacology, University of Iowa Hospitals & Clinics, Iowa City, IA, USA.
Robert WeissDepartment of Internal Medicine, Division of Cardiology, University of Iowa Hospitals & Clinics, Iowa City, IA, USA.
Kyle BradberryFraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Eric B TaylorFraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA; Department of Molecular Physiology and Biophysics, University of Iowa Hospitals & Clinics, Iowa City, IA, USA.
Adam J RauckhorstFraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA; Department of Molecular Physiology and Biophysics, University of Iowa Hospitals & Clinics, Iowa City, IA, USA.
David W DickDepartment of Radiology, Division of Nuclear Medicine, University of Iowa Hospitals & Clinics, Iowa City, IA, USA.
Vamsidhar AkurathiDepartment of Radiology, Division of Nuclear Medicine, University of Iowa Hospitals & Clinics, Iowa City, IA, USA.
Kelly C Falls-HubertMedical Scientist Training Program, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa Hospitals & Clinics, Iowa City, IA, USA.
Brett A WagnerFree Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa Hospitals & Clinics, Iowa City, IA, USA.
Walter A CarterDepartment of Pediatrics and Division of Medical Genetics and Genomics, University of Iowa Hospitals & Clinics, Iowa City, IA, USA.
Kai WangCollege of Public Health, Department of Biostatistics, University of Iowa, Iowa City, IA, USA.
Andrew W NorrisDepartment of Pediatrics and Division of Medical Genetics and Genomics, University of Iowa Hospitals & Clinics, Iowa City, IA, USA; Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Kamal RahmouniDepartment of Neuroscience and Pharmacology, University of Iowa Hospitals & Clinics, Iowa City, IA, USA.
Garry R BuettnerFree Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa Hospitals & Clinics, Iowa City, IA, USA.
Jason M HansenDepartment of Physiology and Developmental Biology, Brigham Young University, Provo, UT, USA.
Douglas R SpitzFree Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa Hospitals & Clinics, Iowa City, IA, USA.
E Dale AbelFraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA; Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Iowa Hospitals & Clinics, Iowa City, IA, USA.
Val C SheffieldDepartment of Pediatrics and Division of Medical Genetics and Genomics, University of Iowa Hospitals & Clinics, Iowa City, IA, USA. Electronic address: val-sheffield@uiowa.edu.
University of Iowa Hospitals and Clinics · USUniversity of Iowa · USFraternal Order of Eagles · USBrigham Young University · USVanderbilt University Medical Center · US
Funding
Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Christopher K Laubenthal · 2000 to 2026
$70.0MTraining CoreP42ES013661 · NIEHS · UNIVERSITY OF IOWA · PI Rachel Frances Marek · 2006 to 2026
$60.3MPulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5MVector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5MRole of the brain Renin-Angiotensin Sys. in Cardiovas and Metabolic RegulationP01HL084207 · NHLBI · UNIVERSITY OF IOWA · PI GROBE, JUSTIN L · 2007 to 2022
$30.2MVanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ALVIN C POWERS · 2012 to 2026
$29.3MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007337 · NIGMS · UNIVERSITY OF IOWA · PI GEYER, PAMELA K., LENTZ, STEVEN R · 1985 to 2020
$15.9MProject 3: MRI Imaging of Redox Active Fe Predicts GBM Responses to Pharmacological AscorbateP01CA217797 · NCI · UNIVERSITY OF IOWA · PI CULLEN, JOSEPH J · 2018 to 2022
$9.6MTreatment of a Complex Retinal Degenerative SyndromeR01EY011298 · NEI · UNIVERSITY OF IOWA · PI SHEFFIELD, VAL C. · 1996 to 2017
$7.3MStem Cell and Organoid CoreP30EY025580 · NEI · UNIVERSITY OF IOWA · PI Budd A Tucker · 2016 to 2026
$6.9MInterdisciplinary approach to retinal disease gene identificationR01EY017168 · NEI · UNIVERSITY OF IOWA · PI SHEFFIELD, VAL C. · 2007 to 2017
$5.9MRegulation of Hepatic Macronutrient Metabolism by Mitochondrial Citrate TransportR01DK104998 · NIDDK · UNIVERSITY OF IOWA · PI TAYLOR, ERIC B · 2015 to 2022
$3.2MBLRD VA I01 BX004249NCI NIH HHS F30 CA213817NCI NIH HHS P01 CA217797NCI NIH HHS P30 CA086862NCI NIH HHS R01 CA169046NCI NIH HHS R01 CA182804NEI NIH HHS P30 EY025580NEI NIH HHS R01 EY011298NEI NIH HHS R01 EY017168NHLBI NIH HHS P01 HL084207NHLBI NIH HHS R01 HL112413NHLBI NIH HHS R01 HL127764NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK054759NIDDK NIH HHS R01 DK104998NIDDK NIH HHS R01 DK115791NIEHS NIH HHS P30 ES005605NIEHS NIH HHS P42 ES013661NIGMS NIH HHS T32 GM007337NIH HHS S10 OD026835
Abstract
Aberrant redox signaling underlies the pathophysiology of many chronic metabolic diseases, including type 2 diabetes (T2D). Methodologies aimed at rebalancing systemic redox homeostasis have had limited success. A noninvasive, sustained approach would enable the long-term control of redox signaling for the treatment of T2D. We report that static magnetic and electric fields (sBE) noninvasively modulate the systemic GSH-to-GSSG redox couple to promote a healthier systemic redox environment that is reducing. Strikingly, when applied to mouse models of T2D, sBE rapidly ameliorates insulin resistance and glucose intolerance in as few as 3 days with no observed adverse effects. Scavenging paramagnetic byproducts of oxygen metabolism with SOD2 in hepatic mitochondria fully abolishes these insulin sensitizing effects, demonstrating that mitochondrial superoxide mediates induction of these therapeutic changes. Our findings introduce a remarkable redox-modulating phenomenon that exploits endogenous electromagneto-receptive mechanisms for the noninvasive treatment of T2D, and potentially other redox-related diseases.
Indexed as
AnimalsDiabetes Mellitus, Type 2Electromagnetic FieldsFemaleHomeostasisHumansMaleMiceMice, Inbred C57BLReactive Oxygen SpeciesTumor Cells, CulturedReactive Oxygen Specieselectromagnetic fieldsglutathioneinsulin resistancelivermitochondriaradical pair mechanismredoxROSsuperoxidetype 2 diabetes
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.