ArticleStructure (London, England : 1993)2021
Structure of the Arabidopsis Glutamate Receptor-like Channel GLR3.2 Ligand-Binding Domain.
Article in Structure (London, England : 1993), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Influence of sound vibrations on plant holobionts: physiological pathways linking root function and rhizospheric microbial interactions.Plant signaling & behavior · 2026Review
- Amino Acids as Multifunctional Molecules in Plants: From Fundamental Metabolism to Precision Agriculture.Plants (Basel, Switzerland) · 2026Review
- Selection and validation of suitable reference genes for qPCR expression analysis in youngFrontiers in plant science · 2026Article
- Understanding the mechanobiology of phytoacoustics through molecular Lens: Mechanisms and future perspectives.Journal of advanced research · 2024Review
- Article
- Two types of GLR channels cooperate differently in light and dark growth of Arabidopsis seedlings.BMC plant biology · 2023Article
- Why did glutamate, GABA, and melatonin become intercellular signalling molecules in plants?eLife · 2023Review
- Merging Signaling with Structure: Functions and Mechanisms of Plant Glutamate Receptor Ion Channels.Annual review of plant biology · 2023Review
- Osmoelectric siphon models for signal and water dispersal in wounded plants.Journal of experimental botany · 2023Article
- Dual localization of the carboxy-terminal tail of GLR3.3 in sieve element-companion cell complex.Communicative & integrative biology · 2023Article
- Roles of Glutamate Receptor-Like Channels (GLRs) in Plant Growth and Response to Environmental Stimuli.Plants (Basel, Switzerland) · 2022Review
- An Insight into Animal Glutamate Receptors Homolog ofPlants (Basel, Switzerland) · 2022Review
- Genome-Wide Identification, Characterization, and Expression Analysis of Glutamate Receptor-like Gene (Plants (Basel, Switzerland) · 2022Article
- Structural insights into function of ionotropic glutamate receptors.Biochemistry (Moscow) Supplement. Series A, Membrane and cell biology · 2022Article
- CaThe EMBO journal · 2022Review
- Ether anesthetics prevents touch-induced trigger hair calcium-electrical signals excite the Venus flytrap.Scientific reports · 2022Article
- Signaling and transport processes related to the carnivorous lifestyle of plants living on nutrient-poor soil.Plant physiology · 2021Review
- Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.Pharmacological reviews · 2021Review
- Structure of the Arabidopsis thaliana glutamate receptor-like channel GLR3.4.Molecular cell · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Glutamate receptor-like channels (GLRs) play important roles in numerous plant physiological processes. GLRs are homologous to ionotropic glutamate receptors (iGluRs) that mediate neurotransmission in vertebrates. Here we determine crystal structures of Arabidopsis thaliana GLR3.2 ligand-binding domain (LBD) in complex with glycine and methionine to 1.58- and 1.75-Å resolution, respectively. Our structures show a fold similar to that of iGluRs, but with several secondary structure elements either missing or different. The closed clamshell conformation of GLR3.2 LBD suggests that both glycine and methionine act as agonists. The mutation R133A strongly increases the constitutive activity of the channel, suggesting that the LBD mutated at the residue critical for agonist binding produces a more stable closed clamshell conformation. Furthermore, our structures explain the promiscuity of GLR activation by different amino acids, confirm evolutionary conservation of structure between GLRs and iGluRs, and predict common molecular principles of their gating mechanisms driven by bilobed clamshell-like LBDs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.