ArticleBiophysical journal2020
Mechanisms of Local Stress Amplification in Axons near the Gray-White Matter Interface.
Article in Biophysical journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Chronic traumatic encephalopathy: A devastating legacy of repetitive concussion.Neurobiology of disease · 2026Review
- Simultaneous Reactive Change in Unmyelinated and Myelinated Axon Segments Following Experimental Diffuse Traumatic Brain Injury.Journal of neurotrauma · 2026Article
- Automated characterization of the gray matter white matter distribution demonstrates age-related decline.Scientific reports · 2026Article
- High-order mesoscale modeling with geometrically conforming gray/white matter interface for traumatic brain injury.Computer methods and programs in biomedicine · 2025Article
- Mechanical Characterisation of Grey, White, and Interface Behaviour in the Brain.Annals of biomedical engineering · 2025Article
- Soccer Heading Exposure-Dependent Microstructural Injury at Depths of Sulci in Adult Amateur Players.Neurology · 2025Article
- Blocking axon-glial mechanotransduction to prevent concussive brain injury.Acta neuropathologica communications · 2025Article
- Biomechanics characterization of an implantable ultrathin intracortical electrode through finite element method.Scientific reports · 2025Article
- Characterizing the microstructural transition at the gray matter-white matter interface: Implementation and demonstration of age-associated differences.NeuroImage · 2025Article
- Association of carotid atherosclerosis with brain tissue integrity and metabolic parameters in type 2 diabetes patients.Frontiers in endocrinology · 2025Article
- No sex difference in the extent of acute mechanical blood-brain barrier disruption after experimental concussion.Acta neuropathologica · 2024Article
- Proteins clump: Mechanics and transport during neurodegeneration.Biophysical journal · 2024Article
- Correlation of brain tissue volume loss with inflammatory biomarkers IL1β, P-tau, T-tau, and NLPR3 in the aging cognitively impaired population.Frontiers in aging neuroscience · 2024Article
- Adverse Outcome Following Mild Traumatic Brain Injury Is Associated with Microstructure Alterations at the Gray and White Matter Boundary.Journal of clinical medicine · 2023Article
- Premature white matter microstructure in female children with a history of concussion.Developmental cognitive neuroscience · 2023Article
- Mechanisms of mechanical load transfer through brain tissue.Scientific reports · 2023Article
- Gray-white matter boundary Z-score and volume as imaging biomarkers of Alzheimer's disease.Frontiers in aging neuroscience · 2023Article
- Immediate induction of varicosities by transverse compression but not uniaxial stretch in axon mechanosensation.Acta neuropathologica communications · 2022Article
- Multiscale Mechanobiology of Brain Injury: Axonal Strain Redistribution.Biophysical journal · 2020Article
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6 authors.
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Abstract
Diffuse axonal injury is a primary neuropathological feature of concussion and is thought to greatly contribute to the classical symptoms of decreased processing speed and memory dysfunction. Although previous studies have investigated the injury biomechanics at the micro- and mesoscale of concussion, few have addressed the multiscale transmission of mechanical loading at thresholds that can induce diffuse axonal injury. Because it has been recognized that axonal pathology is commonly found at anatomic interfaces across all severities of traumatic brain injury, we combined computational, analytical, and experimental approaches to investigate the potential mechanical vulnerability of axons that span the gray-white tissue interface. Our computational models predict that material heterogeneities at the gray-white interface lead to a highly nonuniform distribution of stress in axons, which was most amplified in axonal regions near the interface. This mechanism was confirmed using an analytical model of an individual fiber in a strained bimaterial interface. Comparisons of these collective data with histopathological evaluation of a swine model of concussion demonstrated a notably similar pattern of axonal damage adjacent to the gray-white interface. The results suggest that the tissue property mismatch at the gray-white matter interface places axons crossing this region at greater risk of mechanical damage during brain tissue deformation from traumatic brain injury.
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