ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2021
Associations of Plasma Folate and Vitamin B6 With Blood DNA Methylation Age: An Analysis of One-Carbon Metabolites in the VA Normative Aging Study.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Longitudinal associations of one-carbon metabolism biomarkers with biological and epigenetic aging in older adults in India.GeroScience · 2026Article
- Aging of the adaptive immune system affects the gut microbiome and systemic levels of vitamin B6.Microbiome · 2026Article
- Article
- Dietary pattern modifies associations between dietary factors and pace of epigenetic aging.Frontiers in nutrition · 2026Article
- One-carbon metabolism-related compounds are associated with epigenetic aging biomarkers: results from the cross-sectional National Health and Nutrition Examination Survey 1999-2002.The American journal of clinical nutrition · 2025Article
- Methylation and algorithms in biological aging: a scoping review.Frontiers in aging · 2025Review
- Association between red blood cell folate and accelerated aging in American adults: a cross-sectional study from the national health and nutrition examination survey.Frontiers in nutrition · 2025Article
- Detecting univariate, bivariate, and overall effects of drug mixtures using Bayesian kernel machine regression.The American journal of drug and alcohol abuse · 2024Article
- The Association between Dietary Nutrient Intake and Acceleration of Aging: Evidence from NHANES.Nutrients · 2024Article
- Higher homocysteine and fibrinogen are associated with early-onset post-stroke depression in patients with acute ischemic stroke.Frontiers in psychiatry · 2024Article
- Geroscience and pathology: a new frontier in understanding age-related diseases.Pathology oncology research : POR · 2024Review
- The Role of Methionine-Rich Diet in Unhealthy Cerebrovascular and Brain Aging: Mechanisms and Implications for Cognitive Impairment.Nutrients · 2023Review
- Modulation of DNA methylation by one-carbon metabolism: a milestone for healthy aging.Nutrition research and practice · 2023Review
- Cohort Network: A Knowledge Graph toward Data Dissemination and Knowledge-Driven Discovery for Cohort Studies.Environmental science & technology · 2023Article
- Psychological Stress and Epigenetic Aging in Older Men: The VA Normative Aging Study.Translational medicine of aging · 2023Article
- Epigenetic clocks and female fertility timeline: A new approach to an old issue?Frontiers in cell and developmental biology · 2023Review
- Increased serum homocysteine in first episode and drug-naïve individuals with schizophrenia: sex differences and correlations with clinical symptoms.BMC psychiatry · 2022Article
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
One-carbon metabolism is an important contributor to aging-related diseases; nevertheless, relationships of one-carbon metabolites with novel DNA methylation-based measures of biological aging remain poorly characterized. We examined relationships of one-carbon metabolites with 3 DNA methylation-based measures of biological aging: DNAmAge, GrimAge, and PhenoAge. We measured plasma levels of 4 common one-carbon metabolites (vitamin B6, vitamin B12, folate, and homocysteine) in 715 VA Normative Aging Study participants with at least 1 visit between 1999 and 2008 (observations = 1153). DNA methylation age metrics were calculated using the HumanMethylation450 BeadChip. We utilized Bayesian Kernel Machine Regression models adjusted for chronological age, lifestyle factors, age-related diseases, and study visits to determine metabolites important to the aging outcomes. Bayesian Kernel Machine Regression models allowed for the estimation of the relationships of single metabolites and the cumulative metabolite mixture with methylation age. Log vitamin B6 was selected as important to PhenoAge (β = -1.62 years, 95% CI: -2.28, -0.96). Log folate was selected as important to GrimAge (β = 0.75 years, 95% CI: 0.41, 1.09) and PhenoAge (β = 1.62 years, 95% CI: 0.95, 2.29). Compared to a model where each metabolite in the mixture is set to its 50th percentile, the log cumulative mixture with each metabolite at its 30th (β = -0.13 years, 95% CI: -0.26, -0.005) and 40th percentile (β = -0.06 years, 95% CI: -0.11, -0.005) was associated with decreased GrimAge. Our results provide novel characterizations of the relationships between one-carbon metabolites and DNA methylation age in a human population study. Further research is required to confirm these findings and establish their generalizability.
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