Evidence map›Paper›PMID 33027502›Full record

ArticleBioinformatics (Oxford, England)2021

LipidFinder 2.0: advanced informatics pipeline for lipidomics discovery applications.

Jorge Alvarez-Jarreta, Patricia R S Rodrigues, Eoin Fahy, Anne O'Connor, Anna Price, Caroline Gaud, Simon Andrews, Paul Benton, Gary Siuzdak, Jade I Hawksworth and 3 more

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Lipidome Complexity in Physiological and Pathological Skin Pigmentation.International journal of molecular sciences · 2025
    Review
  4. Article
  5. ADViSELipidomics: a workflow for analyzing lipidomics data.Bioinformatics (Oxford, England) · 2022
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jorge Alvarez-JarretaSchool of Medicine, Systems Immunity Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Patricia R S RodriguesSchool of Medicine, Systems Immunity Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Eoin FahyDepartment of Bioengineering, University of California, San Diego, CA 92037, USA.
Anne O'ConnorSchool of Medicine, Systems Immunity Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Anna PriceSchool of Biosciences, Cardiff University, Cardiff CF10 3AX, UK.
Caroline GaudBioinformatics, Babraham Institute, Cambridge CF24 3AA, UK.
Simon AndrewsBioinformatics, Babraham Institute, Cambridge CF24 3AA, UK.
Paul BentonThe Scripps Research Institute, Center for Metabolomics, La Jolla, CA 92037, USA.
Gary SiuzdakThe Scripps Research Institute, Center for Metabolomics, La Jolla, CA 92037, USA.
Jade I HawksworthSchool of Medicine, Systems Immunity Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Maria Valdivia-GarciaSchool of Medicine, Systems Immunity Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Stuart M AllenSchool of Computer Science and Informatics, Cardiff University, Cardiff CF24 3AA, UK.
Valerie B O'DonnellSchool of Medicine, Systems Immunity Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.

Funding

Metabolomics Technologies to Advance Biomedical ResearchR35GM130385 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI GARY E SIUZDAK · 2019 to 2026
$3.9M
NIGMS NIH HHS R35 GM130385Wellcome TrustWellcome Trust 203014/Z/16/Z
6 · The paper itself

Abstract

summaryWe present LipidFinder 2.0, incorporating four new modules that apply artefact filters, remove lipid and contaminant stacks, in-source fragments and salt clusters, and a new isotope deletion method which is significantly more sensitive than available open-access alternatives. We also incorporate a novel false discovery rate method, utilizing a target-decoy strategy, which allows users to assess data quality. A renewed lipid profiling method is introduced which searches three different databases from LIPID MAPS and returns bulk lipid structures only, and a lipid category scatter plot with color blind friendly pallet. An API interface with XCMS Online is made available on LipidFinder's online version. We show using real data that LipidFinder 2.0 provides a significant improvement over non-lipid metabolite filtering and lipid profiling, compared to available tools. AVAILABILITY AND IMPLEMENTATION: LipidFinder 2.0 is freely available at https://github.com/ODonnell-Lipidomics/LipidFinder and http://lipidmaps.org/resources/tools/lipidfinder. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

Indexed as

LipidomicsSoftwareDatabases, FactualLipidsLipids

Identifiers

PMID33027502
PMCPMC8208733

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.