Evidence map›Paper›PMID 33027418›Full record

ArticleRevista da Sociedade Brasileira de Medicina Tropical2020

Current evidence of neurological features, diagnosis, and neuropathogenesis associated with COVID-19.

Marzia Puccioni-Sohler, André Rodrigues Poton, Milena Franklin, Samya Jezine da Silva, Rodrigo Brindeiro, Amilcar Tanuri

Open access · diamondAbstract read
In one paragraph

Article in Revista da Sociedade Brasileira de Medicina Tropical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Miller Fisher syndrome associated with COVID-19: an up-to-date systematic review.Environmental science and pollution research international · 2021
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Pathophysiological aspects of neuro-COVID.Revista da Sociedade Brasileira de Medicina Tropical · 2022
    Article
  8. Review
  9. Review
  10. Article
  11. Neurological complications and infection mechanism of SARS-COV-2.Signal transduction and targeted therapy · 2021
    Review
  12. Review
  13. Sudomotor dysfunction in patients recovered from COVID-19.Neurophysiologie clinique = Clinical neurophysiology · 2021
    Observational
  14. Article
  15. Review
  16. Article
  17. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Marzia Puccioni-SohlerUniversidade Federal do Estado do Rio de Janeiro, Escola de Medicina e Cirurgia, Rio de Janeiro, RJ, Brasil.ORCID http://orcid.org/0000-0001-6007-9142
André Rodrigues PotonUniversidade Federal do Estado do Rio de Janeiro, Escola de Medicina e Cirurgia, Rio de Janeiro, RJ, Brasil.
Milena FranklinUniversidade Federal do Estado do Rio de Janeiro, Escola de Medicina e Cirurgia, Rio de Janeiro, RJ, Brasil.
Samya Jezine da SilvaUniversidade Federal do Rio de Janeiro, Programa de Pós-Graduação em Doenças Infecciosas e Parasitárias, Rio de Janeiro, RJ, Brasil.
Rodrigo BrindeiroUniversidade Federal do Rio de Janeiro, Instituto de Biologia, Rio de Janeiro, RJ, Brasil.
Amilcar TanuriUniversidade Federal do Rio de Janeiro, Instituto de Biologia, Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro · BRUniversidade Federal do Estado do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent reports indicate that besides respiratory and systemic symptoms among coronavirus disease (COVID-19) patients, the disease has a wide spectrum of neurological manifestations (encephalitis, meningitis, myelitis, acute disseminated encephalomyelitis, metabolic and acute hemorrhagic necrotizing encephalopathy, cerebrovascular diseases, Guillain-Barré syndrome, polyneuritis cranialis, dysautonomia, and myopathies). The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can spread from the respiratory system to the central nervous system, using transneuronal and hematogenous mechanisms. Although not every COVID-19 patient will test positive for the virus in the cerebrospinal fluid exam, the appearance of neurological symptoms associated with SARS-CoV-2 infection reveals the importance of understanding the neurologic manifestations and capacity for neural invasion associated with the pathogen. These aspects are relevant for correct diagnosis and treatment, and for the potential development of vaccines. This review highlights the latest evidence of SARS-CoV-2 infection with a focus on neurological involvement and potential neuropathogenesis mechanisms.

Indexed as

BetacoronavirusCoronavirus InfectionsPandemicsPneumonia, ViralCentral Nervous System DiseasesClinical Laboratory TechniquesCOVID-19COVID-19 TestingHumansSARS-CoV-2

Identifiers

PMID33027418
PMCPMC7534972
OpenAlexW3092203535

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.