Evidence map›Paper›PMID 33027361›Full record

ArticleActa cirurgica brasileira2020

Omeprazole and adenocarcinoma in the stomach of rats submitted to duodenogastric reflux. Is there a protective effect?

Rosângela Lucinda Rocha Monteiro, Maria Aparecida Marchesan Rodrigues Kobayasi, Marina Rachel de Araujo, Dafny Rocha Monteiro, Nelson Adami Andreollo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta cirurgica brasileira, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Rosângela Lucinda Rocha MonteiroMaster, Assistant Professor, School of Medicine, Universidade do Vale do Sapucaí (UNIVÁS), Pouso Alegre-MG, Brazil. Conception and design of the study, technical procedures, acquisition and interpretation of data, statistics analysis, manuscript preparation.ORCID http://orcid.org/0000-0002-2907-0614
Maria Aparecida Marchesan Rodrigues KobayasiPhD, Full Professor, Department of Pathology, Medical School, Universidade Estadual Paulista (UNESP), Botucatu-SP, Brazil. Analysis and interpretation of data, histopathological examinations, statistics analysis, manuscript preparation, critical revision.ORCID http://orcid.org/0000-0002-8355-1929
Marina Rachel de AraujoBiologist, Experimental Surgery Laboratory, School of Medical Sciences, Universidade Estadual de Campinas (UNICAMP), Brazil. Acquisition of data, technical procedures.ORCID http://orcid.org/0000-0003-1653-670X
Dafny Rocha MonteiroGraduate student, Centro Universitário de Faculdades de Ensino Associadas (UNIFAE), Sao Joao da Boa Vista-SP, Brazil. Acquisition of data, technical procedures.ORCID http://orcid.org/0000-0001-6434-9963
Nelson Adami AndreolloPhD, Full Professor, Digestive Diseases Surgical Unit and Gastrocentro, School of Medical Sciences, UNICAMP, Campinas-SP, Brazil. Conception and design of the study, interpretation of data, manuscript preparation, critical revision.ORCID http://orcid.org/0000-0001-7452-1165
Universidade Estadual de Campinas (UNICAMP) · BRCentro Universitário das Faculdades Metropolitanas Unidas · BRUniversidade do Vale do Sapucaí · BRUniversidade Estadual Paulista (Unesp) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the role of omeprazole and nitrites on the gastric mucosa of rats submitted to specific techniques to induce duodenogastric reflux.

methodsOne hundred and twenty Wistar rats were divided into three groups: Group I (n=40) -gastrotomy; Group II (n=40) - duodenogastric reflux after gastrojejunoanastomosis latero-lateral (DGR); Group III (n=40) - retrograde duodenogastric reflux through the pylorus (DGR-P). The groups were divided into 4 subgroups of 10 animals, respectively treated for 16 weeks with water, omeprazole 1.6 mg / rat / day, nitrite 600 mg / kg / day and omeprazole plus nitrite simultaneously.

resultsThe proliferative lesions found were: squamous hyperplasia - 69.1%, adenomatous hyperplasia in the anastomosis - 29.1% and prepyloric adenomatous hyperplasia - 42.5%. Adenocarcinomas were registered in 7 animals (5.8%): one in Group I (omeprazole plus nitrite), two in Group II (omeprazole and nitrite plus omeprazole) and four in Group III (water, nitrite, omeprazole and omeprazole plus nitrite).

conclusionsThe occurrence of squamous hyperplasia, adenomatous hyperplasia and adenocarcinoma increased after gastrojejunal anastomoses, which cause duodenogastric reflux. The association of omeprazole did not protect the development of proliferative lesions and cancer induced by duodenogastric reflux in rats.

Indexed as

AdenocarcinomaDuodenogastric RefluxOmeprazoleProton Pump InhibitorsAnimalsGastric MucosaHumansRatsRats, WistarOmeprazoleProton Pump Inhibitors

Identifiers

PMID33027361
PMCPMC7531054
OpenAlexW3090838379

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.