Evidence map›Paper›PMID 33027360›Full record

ArticleActa cirurgica brasileira2020

The outcomes of dexmedetomidine and calcitriol on flap viability.

Mustafa Sırrı Kotanoğlu, Aylin Akbulut, Koray Gürsoy, Gökhan Koca, Namık Özcan, Nihat Yumuşak, Mehmet Şenes, Gül Kırtıl, Meliha Korkmaz

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta cirurgica brasileira, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 3 countries.

Mustafa Sırrı KotanoğluMD, Department of Anesthesiology and Reanimation, University of Health Sciences, Ankara Training and Research Hospital, Ankara, Turkey. Substantive scientific and intellectual contributions to the study.ORCID http://orcid.org/0000-0002-6906-573X
Aylin AkbulutMD, Department of Nuclear Medicine, University of Health Sciences, Ankara Training and Research Hospital, Ankara, Turkey. Conception and design of the study, analysis and interpretation of data.ORCID http://orcid.org/0000-0003-4665-7895
Koray GürsoyMD, Associate Professor, Department of Plastic, Reconstructive and Aesthetic Surgery, University of Health Sciences, Ankara Training and Research Hospital, Ankara, Turkey. Technical procedures.ORCID http://orcid.org/0000-0002-7730-7225
Gökhan KocaAssociate Professor, Department of Nuclear Medicine, University of Health Sciences, Ankara Training and Research Hospital, Ankara, Turkey. Conception and design of the study, analysis and interpretation of data.ORCID http://orcid.org/0000-0003-2842-9223
Namık ÖzcanAssociate Professor, Department of Anesthesiology and Reanimation, University of Health Sciences, City Hospital, Ankara, Turkey. Substantive scientific and intellectual contributions to the study.ORCID http://orcid.org/0000-0001-9310-712X
Nihat YumuşakAssociate Professor, Department of Pathology, Harran University Faculty of Veterinary Medicine, Sanliurfa, Turkey. Histopathological examinations.ORCID http://orcid.org/0000-0002-9299-2902
Mehmet ŞenesAssociate Professor, Department of Biochemistry, University of Health Sciences, Ankara Training and Research Hospital, Ankara, Turkey. Analysis and interpretation of data.ORCID http://orcid.org/0000-0002-7924-5478
Gül KırtılMD, Department of Biochemistry, University of Health Sciences, Ankara Training and Research Hospital, Ankara, Turkey. Analysis and interpretation of data.ORCID http://orcid.org/0000-0002-8280-9000
Meliha KorkmazMD, PhD, Department of Anesthesiology and Reanimation, University of Health Sciences, Ankara Training and Research Hospital, Ankara, Turkey. Critical revision, final approval.ORCID http://orcid.org/0000-0002-2258-8277
Ministry of Health · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate protective effects of dexmedetomidine, calcitriol and their combination.

methodsForty Wistar-albino rats were divided into 4 groups; group of Sham (Group Sham); group of dexmedetomidine (Group DEX); group of calcitriol (Group CAL) and group of dexmedetomidineandcalcitriol (Group DEX-CAL). Photographic analysis was used for macroscopic analysis and perfusion analyses were evaluated by scintigraphy. Additionally, tissue malondialdehyde (MDA) and total oxidant status (TOS) and total antioxidant activity (TAS) were recorded and oxidative stress index (OSI) was calculated. Each flap was assessed by histopathology.

resultsCompared to Group Sham, the viable flap areas were higher in all treatment groups both by photographic image analyses and perfusion analyses (p<0.05). Group DEX-CAL had the highest viable flap percentage both in scintigraphic and photographic analyses; whereas Group Sham had the lowest viable flap percentage. Similarly, TAS and MDA levels were elevated and TOS levels were declined in all treatment groups compared to Group Sham (p<0.005). Histopathological analysis at flap demarcation zone confirmed neovascularization was significantly higher and edema, necrosis and inflammation were significantly lower in all treatment groups compared to Group Sham.

conclusionThe outcomes show that additional premedication with either dexmedetomidine or calcitriol or their combination reduces ischemia-reperfusion injury of flap area and show significant increase in the percentage of viable flap tissue.

Indexed as

CalcitriolDexmedetomidineReperfusion InjurySurgical FlapsAnimalsRatsRats, WistarCalcitriolDexmedetomidine

Identifiers

PMID33027360
PMCPMC7531053
OpenAlexW3091510859

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.