ArticlePloS one2020
Preocular sensor system for concurrent monitoring of glucose levels and dry eye syndrome using tear fluids.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Wearable Electrochemical Glucose Sensors for Fluid Monitoring: Advances and Challenges in Non-Invasive and Minimally Invasive Technologies.Biosensors · 2025Review
- A bibliometric and visualization analysis of electrochemical biosensors for early diagnosis of eye diseases.Frontiers in medicine · 2024Article
- Chromophoric cerium oxide nanoparticle-loaded sucking disk-type strip sensor for optical measurement of glucose in tear fluid.Biomaterials research · 2023Article
- Flexible and Wearable Biosensors for Monitoring Health Conditions.Biosensors · 2023Review
- [Research progress on minimally invasive and non-invasive blood glucose detection methods].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2023Article
- Smartphone-Based Electrochemical Systems for Glucose Monitoring in Biofluids: A Review.Sensors (Basel, Switzerland) · 2022Review
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Authors and funding
4 authors.
Funding
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Abstract
The present study demonstrated a noninvasive preocular sensor system for the concurrent monitoring of diabetes and one of its prevalent complications, dry eye syndrome (DES), using tear fluids. Two distinct sensors, i.e., the glucose and DES sensors, were prepared and encased together in a single housing unit to produce the sensor system, and the tip was designed to be in contact with the eye surface noninvasively to collect and deliver tear fluid to the sensors. The glucose sensor was modified from a commercially available electrochemical sensor to allow for the measurement of glucose concentrations, even in a small amount of collected tear fluid. The DES sensor was equipped with a microchannel spaced with two parallel electrodes to determine the amount of collected tear fluid. In vivo experimental results revealed that with the collected tear fluid of about 0.6-1.0 μl, the sensor system estimated the blood glucose concentrations with acceptable accuracy compared with that of the glucometer in clinical use. The DES condition in animals was diagnosed with high sensitivity (91.7%) and specificity (83.3%).
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