Evidence map›Paper›PMID 33026960›Full record

ArticleMolecular biology of the cell2020

Regulation of meiotic progression by Sertoli-cell androgen signaling.

Hailey Larose, Travis Kent, Qianyi Ma, Adrienne Niederriter Shami, Nadia Harerimana, Jun Z Li, Saher Sue Hammoud, Mary Ann Handel

Open access · greenAbstract read
In one paragraph

Article in Molecular biology of the cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
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  7. Sertoli cells as a hub in testicular development and male reproductive.Frontiers in cell and developmental biology · 2025
    Review
  8. Hormone Regulation in Testicular Development and Function.International journal of molecular sciences · 2024
    Review
  9. Review
  10. Review
  11. Steroid hormone signaling: multifaceted support of testicular function.Frontiers in cell and developmental biology · 2023
    Review
  12. Article
  13. Review
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  15. Article
  16. Article
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Hailey LaroseDepartment of Human Genetics, University of Michigan, Ann Arbor, MI 48109.
Travis KentThe Jackson Laboratory, Bar Harbor, ME 04609.
Qianyi MaDepartment of Human Genetics, University of Michigan, Ann Arbor, MI 48109.
Adrienne Niederriter ShamiDepartment of Human Genetics, University of Michigan, Ann Arbor, MI 48109.
Nadia HarerimanaCollege of the Atlantic, Bar Harbor ME 04609.
Jun Z LiDepartment of Human Genetics, University of Michigan, Ann Arbor, MI 48109.
Saher Sue HammoudDepartment of Human Genetics, University of Michigan, Ann Arbor, MI 48109.
Mary Ann HandelThe Jackson Laboratory, Bar Harbor, ME 04609.
University of Michigan · USJackson Laboratory · USCollege of the Atlantic · US

Funding

Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI Mark D ADAMS · 1985 to 2026
$61.9M
MICHIGAN MEDICAL SCIENTIST TRAINING PROGRAMT32GM007863 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLLINS, KATHLEEN L. · 1985 to 2024
$38.3M
CELL CYCLE REGULATION DURING SPERMATOGENESISR01HD033816 · NICHD · UNIVERSITY OF TENNESSEE KNOXVILLE · PI HANDEL, MARY ANN · 1996 to 2016
$4.7M
Contributions of Sperm Chromatin to development: A Myth or Reality?DP2HD091949 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAMMOUD, SAHER SUE · 2016 to 2016
$2.3M
Career Training in Reproductive BiologyT32HD079342 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Suzanne M MOENTER · 2014 to 2026
$2.3M
Comprehensive mapping of mouse testis cell types and spermatogenic stages by single-cell RNA sequencingR21HD090371 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAMMOUD, SAHER SUE · 2018 to 2019
$444k
Elucidating the Role of TCF21+ Mesenchymal Cells in Testis Tissue Homeostasis and RegenerationF30HD097961 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHAMI, ADRIENNE NIEDERRITER · 2018 to 2020
$108k
NCI NIH HHS P30 CA034196NICHD NIH HHS DP2 HD091949NICHD NIH HHS F30 HD097961NICHD NIH HHS R01 HD033816NICHD NIH HHS R21 HD090371NICHD NIH HHS T32 HD079342NIGMS NIH HHS T32 GM007863
6 · The paper itself

Abstract

Androgen receptor (AR) signaling in Sertoli cells is known to be important for germ-cell progression through meiosis, but the extent to which androgens indirectly regulate specific meiotic stages is not known. Here, we combine synchronization of spermatogenesis, cytological analyses and single-cell RNAseq (scRNAseq) in the

Indexed as

AndrogensAnimalsMaleMeiosisMeiotic Prophase IMiceMice, Inbred C57BLMice, KnockoutProphaseReceptors, AndrogenSequence Analysis, RNASertoli CellsSignal TransductionSingle-Cell AnalysisSpermatocytesSpermatogenesisAndrogensReceptors, Androgen

Identifiers

PMID33026960
PMCPMC7851862
OpenAlexW3092456470

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.