Evidence map›Paper›PMID 33026931›Full record

ArticleMolecular biology of the cell2020

Microtubule-dependent pushing forces contribute to long-distance aster movement and centration in

Taylor Sulerud, Abdullah Bashar Sami, Guihe Li, April Kloxin, John Oakey, Jesse Gatlin

Open access · greenAbstract read
In one paragraph

Article in Molecular biology of the cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Building on-chip cytoskeletal circuits via branched microtubule networks.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Taylor SulerudDepartment of Molecular Biology, University of Wyoming, Laramie, WY 82071.
Abdullah Bashar SamiDepartment of Molecular Biology, University of Wyoming, Laramie, WY 82071.
Guihe LiDepartment of Chemical Engineering, University of Wyoming, Laramie, WY 82071.
April KloxinDepartment of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716.
John OakeyDepartment of Chemical Engineering, University of Wyoming, Laramie, WY 82071.
Jesse GatlinDepartment of Molecular Biology, University of Wyoming, Laramie, WY 82071.
University of Wyoming · USUniversity of Delaware · US

Funding

Wyoming INBRE Phase 4- Equipment Supplement for x-ray diffractometer for Center for Advanced Scientific InstrumentationP20GM103432 · NIGMS · UNIVERSITY OF WYOMING · PI Nicolas A. Blouin · 2012 to 2026
$56.8M
Integration of Xenopus extract and microfluidics to study organelle size scalingR01GM113028 · NIGMS · UNIVERSITY OF WYOMING · PI LEVY, DANIEL LEON · 2015 to 2019
$1.3M
Mechanics of Microtubule Aster Growth and Positioning: Instrumentation SupplementR01GM135568 · NIGMS · UNIVERSITY OF WYOMING · PI GATLIN, JESSE C · 2020 to 2023
$1.3M
NIGMS NIH HHS P20 GM103432NIGMS NIH HHS R01 GM113028NIGMS NIH HHS R01 GM135568
6 · The paper itself

Abstract

During interphase of the eukaryotic cell cycle, the microtubule (MT) cytoskeleton serves as both a supportive scaffold for organelles and an arborized system of tracks for intracellular transport. At the onset of mitosis, the position of the astral MT network, specifically its center, determines the eventual location of the spindle apparatus and ultimately the cytokinetic furrow. Positioning of the MT aster often results in its movement to the center of a cell, even in large blastomeres hundreds of microns in diameter. This translocation requires positioning forces, yet how these forces are generated and then integrated within cells of various sizes and geometries remains an open question. Here we describe a method that combines microfluidics, hydrogels, and

Indexed as

AnimalsCentrosomeCytoplasmic DyneinsCytoskeletonDyneinsInterphaseIntracellular FluidMicrotubulesMitosisMovementOrganellesSpindle ApparatusXenopus laevisXenopus ProteinsCytoplasmic DyneinsDyneinsXenopus Proteins

Identifiers

PMID33026931
PMCPMC7851858
OpenAlexW3092365114

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.