Evidence map›Paper›PMID 33026594›Full record

ArticleJapanese journal of ophthalmology2020

Reduced steroid-induced intraocular pressure elevation in tacrolimus-treated refractory allergic ocular diseases.

Dai Miyazaki, Daisuke Shimizu, Atsuki Fukushima, Nobuyuki Ebihara, Eiichi Uchio, Jun Shoji, Kenichi Namba, Yoshitsugu Inoue, Yuichi Ohashi, Shigeki Okamoto and 2 more

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Article in Japanese journal of ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Dai MiyazakiDivision of Ophthalmology and Visual Science, Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago, Tottori, 683-8504, Japan. miyazaki-ttr@umin.ac.jp.
Daisuke ShimizuDivision of Ophthalmology and Visual Science, Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago, Tottori, 683-8504, Japan.
Atsuki FukushimaDepartment of Ophthalmology, Kochi Medical School, Kochi, Japan.
Nobuyuki EbiharaDepartment of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan.
Eiichi UchioDepartment of Ophthalmology, School of Medicine, Fukuoka University, Fukuoka, Japan.
Jun ShojiDivision of Ophthalmology, Department of Visual Sciences, Nihon University School of Medicine, Tokyo, Japan.
Kenichi NambaDepartment of Ophthalmology, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
Yoshitsugu InoueDivision of Ophthalmology and Visual Science, Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago, Tottori, 683-8504, Japan.
Yuichi OhashiDepartment of Ophthalmology, Ehime University School of Medicine, Toon, Ehime, Japan.
Shigeki OkamotoOkamoto Eye Clinic, Matsuyama, Ehime, Japan.
Etsuko TakamuraDepartment of Ophthalmology, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.
Hiroshi FujishimaDepartment of Ophthalmology, Tsurumi University Dental Hospital, Yokohama, Kanagawa, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine whether topical tacrolimus can lessen steroid-induced intraocular pressure (IOP) elevation. STUDY

designOpen cohort post hoc analysis study.

methodsFive hundred eleven patients with vernal keratoconjunctivitis or atopic keratoconjunctivitis (mean age 17.0 ± 9.2 years) were studied. All 511 patients were treated with topical tacrolimus with or without topical steroids, and the changes in IOP were measured monthly for 3 months. The elevation in IOP induced by use of topical steroids was calculated using mixed linear regression analyses. The relationship between the elevation in IOP within 4 weeks and the use or nonuse of tacrolimus reported in published data was analyzed using metaregression analysis to estimate the effects of tacrolimus on the IOP in eyes treated with topical steroids.

resultsThe mean topical steroid-induced IOP elevation in tacrolimus-treated eyes was lower, by 5.2 mmHg (P = 0.04), than that in earlier published data without tacrolimus as the control. In the tacrolimus-treated eyes, the mean betamethasone-induced IOP elevation was 1.3 mmHg without discontinuation of the steroid. Metaregression analysis indicated that glaucoma history and younger age had significant effects on topical steroid-induced IOP elevation, by 4.0 mmHg (P = 0.002) and 3.9 mmHg (P = 0.01), respectively. In tacrolimus-treated eyes, the most significant effect on the IOP was associated with glaucoma history or medication; however, its effect on the IOP was limited to 1.7 mmHg elevation (P = 0.006).

conclusionsTopical tacrolimus may lessen the steroid-induced elevation in IOP in younger individuals and may be a good adjunctive therapy to avoid IOP elevation in refractory cases.

Indexed as

GlaucomaOcular HypertensionAdolescentBetamethasoneHumansIntraocular PressureTacrolimusTonometry, OcularBetamethasoneTacrolimusAllergic conjunctivitisIntraocular pressure (IOP)Secondary glaucomaTacrolimus

Identifiers

PMID33026594

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.