Evidence map›Paper›PMID 33026590›Full record

ArticleJournal of endocrinological investigation2021

Pre-operative micronutrient deficiencies in patients with severe obesity candidates for bariatric surgery.

M Pellegrini, F Rahimi, S Boschetti, A Devecchi, A De Francesco, M V Mancino, M Toppino, M Morino, G Fanni, V Ponzo and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of endocrinological investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 6 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 6 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Low-energy diets before metabolic bariatric surgery: A systematic review of the effect on total body weight, liver volume, glycemia and side effects.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 3 countries.

M PellegriniDepartment of Medical Sciences, University of Turin, c.so AM Dogliotti 14, 10126, Torino, Italy.
F RahimiUnit of Clinical Nutrition, "Città della Salute e della Scienza" Hospital of Turin, Turin, Italy.
S BoschettiUnit of Clinical Nutrition, "Città della Salute e della Scienza" Hospital of Turin, Turin, Italy.
A DevecchiDepartment of Medical Sciences, University of Turin, c.so AM Dogliotti 14, 10126, Torino, Italy.
A De FrancescoUnit of Clinical Nutrition, "Città della Salute e della Scienza" Hospital of Turin, Turin, Italy.
M V MancinoUnit of Clinical Nutrition, "Città della Salute e della Scienza" Hospital of Turin, Turin, Italy.
M ToppinoDepartment of Surgical Sciences, University of Turin, Turin, Italy.
M MorinoDepartment of Surgical Sciences, University of Turin, Turin, Italy.
G FanniDepartment of Medical Sciences, University of Turin, c.so AM Dogliotti 14, 10126, Torino, Italy.
V PonzoDepartment of Medical Sciences, University of Turin, c.so AM Dogliotti 14, 10126, Torino, Italy.
E MarzolaDepartment of Neuroscience, University of Turin, Turin, Italy.
G Abbate DagaDepartment of Neuroscience, University of Turin, Turin, Italy.
F BroglioDepartment of Medical Sciences, University of Turin, c.so AM Dogliotti 14, 10126, Torino, Italy.
E GhigoDepartment of Medical Sciences, University of Turin, c.so AM Dogliotti 14, 10126, Torino, Italy.
S BoDepartment of Medical Sciences, University of Turin, c.so AM Dogliotti 14, 10126, Torino, Italy. simona.bo@unito.it.ORCID http://orcid.org/0000-0001-6862-8628
University of Turin · ITAzienda Ospedaliera Citta' della Salute e della Scienza di Torino · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIn patients with obesity, micronutrient deficiencies have been reported both before and after bariatric surgery (BS). Obesity is a chronic pro-inflammatory status, and inflammation increases the risk of micronutrient malnutrition. Our objective was to assess in pre-BS patients the prevalence of micronutrient deficiencies and their correlation with blood values of C-reactive protein (CRP).

methodsAnthropometric data, instrumental examinations, and blood variables were centrally measured in the first 200 patients undergoing a pre-BS evaluation at the "Città della Salute e della Scienza" Hospital of Torino, starting from January 2018.

resultsAt least one micronutrient deficiency was present in 85.5% of pre-BS patients. Vitamin D deficiency was the most prevalent (74.5%), followed by folate (33.5%), iron (32%), calcium (13%), vitamin B12 (10%), and albumin (5.5%) deficiency. CRP values were high (> 5 mg/L) in 65% of the patients. These individuals showed increased rate of iron, folate, vitamin B12 deficiency, and a higher number of micronutrient deficiencies. In a multiple logistic regression model, increased CRP levels were significantly associated with deficiencies of vitamin B12 (OR = 5.84; 95% CI 1.25-27.2; p = 0.024), folate (OR = 4.02; 1.87-8.66; p < 0.001), and with the presence of ≥ 2 micronutrient deficiencies (OR = 2.31; 1.21-4.42; p = 0.01).

conclusionsMicronutrient deficiencies are common in patients with severe obesity undergoing BS, especially when inflammation is present. In the presence of increased CRP values before surgery, it might be advisable to search for possible multiple micronutrient deficiencies.

Indexed as

Nutritional StatusPreoperative CareAdolescentAdultAgedBariatric SurgeryCross-Sectional StudiesFemaleFollow-Up StudiesHumansMaleMalnutritionMicronutrientsMiddle AgedObesity, MorbidPrognosisMicronutrientsBariatric surgeryC-reactive proteinMicronutrient deficiencySevere obesityVitamin D

Identifiers

PMID33026590
PMCPMC8195915
OpenAlexW3092365107

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.