Evidence map›Paper›PMID 33026537›Full record

Trial reportInternational orthopaedics2021

Clinical evaluation of micro-fragmented adipose tissue as a treatment option for patients with meniscus tears with osteoarthritis: a prospective pilot study.

Gerard A Malanga, Paul S Chirichella, Nathan S Hogaboom, Teresa Capella

Registry-linked trialOpen access · hybridAbstract readClinical Trial, Phase II
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International orthopaedics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03714659 (Clinical Evaluation of Autologous Micro-fragmented Adipose Tissue as a Treatment Option for Meniscus Tears), which is not on this map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03714659 phase2completednot on this map

Clinical Evaluation of Autologous Micro-fragmented Adipose Tissue as a Treatment Option for Meniscus Tears

TypeinterventionalSponsorNew Jersey Regenerative Institute, LLCRan2017 to 2018Enrolled20ConditionsTibial Meniscus Injuries, Osteoarthritis, KneeArmsLipogems
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
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  7. Article
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  12. Review
  13. The Role of Ultrasound in the Diagnosis and Treatment of Meniscal Injuries.Current reviews in musculoskeletal medicine · 2024
    Review
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  15. Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Gerard A MalangaNew Jersey Regenerative Institute LLC, 197 Ridgedale Ave Suite 210, Cedar Knolls, NJ, 07927, USA. gmalangamd@hotmail.com.ORCID 0000-0001-8384-7036
Paul S ChirichellaDepartment of Physical Medicine and Rehabilitation, New Jersey Medical School, Rutgers University, Newark, NJ, USA.
Nathan S HogaboomKessler Foundation, West Orange, NJ, USA.
Teresa CapellaNew Jersey Regenerative Institute LLC, 197 Ridgedale Ave Suite 210, Cedar Knolls, NJ, 07927, USA.
Rutgers, The State University of New Jersey · USCalifornia Institute for Regenerative Medicine · US

Funding

Technology Development P2CHD086843 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AMBROSIO, FABRISIA · 2015 to 2024
$10.5M
NICHD NIH HHS P2C HD086843
6 · The paper itself

Abstract

purposeThe management of knee pain secondary to meniscal tears with osteoarthritis is limited by the poor inherent healing potential of the meniscus. Previous studies have reported on the benefit of autologous micro-fragmented fat as a therapeutic for various knee pathologies. The goal of this prospective pilot study was to determine the safety and potential treatment effect of micro-fragmented adipose tissue injection for patients with knee pain secondary to osteoarthritis and meniscal tears who have failed conservative management.

methodsTwenty subjects with knee pain secondary to osteoarthritis with associated meniscal tear after failed conservative management were enrolled in the study. Numeric Pain Scale (NPS) and Knee Injury and Osteoarthritis Outcome Scale (KOOS) following ultrasound-guided intra-meniscal and intra-articular micro-fragmented adipose tissue injections were examined at three, six and 12 months.

resultsThe mean NPS revealed a significant decrease in patient pain at the 1-year time point compared with baseline (5.45 to 2.21, p < .001). Similarly, overall, mean KOOS symptoms significantly improved from 57.7 to 78.2 (p < .001), with all 4 KOOS subscales demonstrating significant improvement at the final one year follow-up. One subject developed uncomplicated cellulitis at the harvest site which was treated with oral antibiotics. Other complications were minor and mostly limited to adipose harvest.

conclusionThis study demonstrated that micro-fragmented adipose tissue injected directly into a torn meniscus and knee joint using ultrasound guidance represents a safe and potentially efficacious treatment option for patients with knee pain suffering from degenerative arthritis and degenerative meniscal tears. A larger, randomized, controlled trial is warranted to determine efficacy.

trial registrationClinicaltrials.org Identifier: NCT03714659.

Indexed as

Knee InjuriesMeniscusOsteoarthritis, KneeAdipose TissueHumansPilot ProjectsProspective StudiesTreatment OutcomeAdipose tissueInjectionsIntra-articularKnee injuriesKnee osteoarthritisMeniscusUltrasonography

Identifiers

PMID33026537
PMCPMC7843556
OpenAlexW3092554145

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.