SynthesisSurgical endoscopy2021
Extrahepatic biliary tract visualization using near-infrared fluorescence imaging with indocyanine green: optimization of dose and dosing time.
Synthesis in Surgical endoscopy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Back to the battlefield: minimally invasive management of postcholecystectomy remnants: a systematic appraisal of safety and efficacy.Surgery today · 2026Pooled it
- Investigation of the optimal indocyanine green dose in real-time fluorescent cholangiography during laparoscopic cholecystectomy with an ultra-high-definition 4K fluorescent system: a randomized controlled trial.Updates in surgery · 2023Trial
- Laboratory scoring system to predict hepatic indocyanine green clearance ability during fluorescence imaging-guided laparoscopic hepatectomy.World journal of gastrointestinal surgery · 2023Trial
- Comparative effectiveness of nasobiliary versus intravenous indocyanine green fluorescence guidance for early laparoscopic cholecystectomy after ERCP: a retrospective cohort study.Updates in surgery · 2026Article
- Near-infrared fluorescence imaging improves biliary visualization and perioperative outcomes in difficult laparoscopic cholecystectomy: implications for future clinical studies.Surgical endoscopy · 2026Article
- Indocyanine green fluorescence navigation for extrahepatic bile duct visualization in laparoscopic cholecystectomy: a prospective cohort study.Annals of medicine and surgery (2012) · 2026Article
- Low‑dose indocyanine green fluorescence cholangiography in laparoscopic cholecystectomy: visualization performance across validated risk scores.Langenbeck's archives of surgery · 2026Article
- How low can you go? Intraoperative microdosing of indocyanine green for fluorescence cholangiography during laparoscopic cholecystectomy.Surgical endoscopy · 2025Article
- Indocyanine green fluorescence-guided surgery in the emergency setting: the WSES international consensus position paper.World journal of emergency surgery : WJES · 2025Article
- Indocyanine green fluorescence improves safety in laparoscopic cholecystectomy using the Fundus First technique: a retrospective study.Frontiers in surgery · 2025Article
- Article
- The application of real-time indocyanine green fluorescence cholangiography in laparoscopic living donor left lateral sectionectomy.Hepatobiliary surgery and nutrition · 2024Article
- Surgical strategies for challenging common bile duct stones in the endoscopic era: A comprehensive review of current evidence.World journal of gastrointestinal endoscopy · 2024Review
- Near-infrared cholangiography with intragallbladder indocyanine green injection in minimally invasive cholecystectomy.World journal of gastrointestinal surgery · 2024Review
- Semi-automatic standardized analysis method to objectively evaluate near-infrared fluorescent dyes in image-guided surgery.Journal of biomedical optics · 2024Article
- Real-time fluorescence-guided adhesiolysis with indocyanine green in intra-abdominal surgery (with video).Scientific reports · 2024Review
- Determining the patency of biliary tracts in dogs with gallbladder mucocele using near-infrared cholangiography with indocyanine green.PloS one · 2024Article
- Identification of the ideal weight-based indocyanine green dose for fluorescent cholangiography.Surgical endoscopy · 2023Article
- Indocyanine green fluorescent cholangiography improves the clinical effects of difficult laparoscopic cholecystectomy.Surgical endoscopy · 2023Article
- Preliminary experience with a new robotic technique to facilitate distal pancreatectomy with spleen preservation: left lateral approach in right lateral decubitus position.Journal of robotic surgery · 2023Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe dose and dosing time of indocyanine green (ICG) vary among fluorescence cholangiography (FC) studies. The purpose of this prospective, randomized, exploratory clinical trial was to optimize the dose and dosing time of ICG.
methodsPubMed was searched to determine the optimal dose. To optimize the dosing time of ICG, a clinical trial was designed with two parts. The first part included patients with T tubes for more than 1 month. After the patient was injected with ICG, bile was collected at 10 time points to explore the change and trends of bile fluorescence intensity (FI). In addition, the results of the first experiment were used to setup a randomized controlled trial (RCT) that aimed to find the optimal dosing timing for ICG injections for laparoscopic cholecystectomy (LC). During surgery, imaging data were collected for analysis.
resultsAfter performing a systematic review, the ICG injection dose for each patient in the clinical trial was 10 mg. Five patients were included in the first part of the study. Bile collected 8 h after ICG injection had a higher FI than bile collected at other time points (p < 0.05), and the FI of bile collected 20 h after ICG injection was nearly zero. In the second part of the experiment, 4 groups of patients (6 patients per group) were injected with 10 mg ICG at 8, 10, 12 and 14 h prior to surgery. The distribution of bile duct FI (p = 0.001), liver FI (p < 0.001), and common bile duct (CBD)-to-liver contrast (p = 0.001) were not the same in each group. Further analysis with the Bonferroni method revealed the following: (1) the FI of the CBD in the 8 h group was significantly different from that in the 14 h group (adjusted p < 0.001); (2) the liver FI of the 8 h group was higher than that of the 10 h group (adjusted p = 0.042) and the 14 h group (adjusted p < 0.001); and (3) the CBD-to-liver contrast of the 8 h group was lower than that of the 10 h group (adjusted p = 0.013) and the 14 h group (adjusted p = 0.001).
conclusionICG FC enables the real-time identification of extrahepatic bile ducts. The optimal effect of FC can be achieved by performing 10 mg ICG injections 10 to 12 h prior to surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.