ArticleClinical neuroradiology2021
Relaxation-Enhanced Angiography Without Contrast and Triggering (REACT) for Fast Imaging of Extracranial Arteries in Acute Ischemic Stroke at 3 T.
Article in Clinical neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Free-breathing, blood-flow-independent, three-dimensional relaxation-enhanced angiography without contrast and triggering (REACT) for aorta measurement and diagnosis in patients with aortic disease: a comparison with computed tomography angiography.Quantitative imaging in medicine and surgery · 2026Article
- Simultaneous Visualization of the Carotid and Subclavian Arteries Using Non-Contrast-Enhanced MR Angiography With a 3D Fast Field Echo Sequence and Time-Spatial Labeling Inversion Pulse: A Comparison With 3D Time-of-Flight MR Angiography.Journal of magnetic resonance imaging : JMRI · 2026Article
- Non-contrast-enhanced MR-angiography of the abdominal arteries: intraindividual comparison between relaxation-enhanced angiography without contrast and triggering (REACT) and 4D contrast-enhanced MR-angiography.Abdominal radiology (New York) · 2025Article
- Non-contrast-enhanced MR-angiography of Extracranial Arteries in Acute Ischemic Stroke at 1.5 Tesla Using Relaxation-Enhanced Angiography Without Contrast and Triggering (REACT).Clinical neuroradiology · 2025Article
- Sub-1-min relaxation-enhanced non-contrast non-triggered cervical MRA using compressed SENSE with deep learning reconstruction in healthy volunteers.European radiology experimental · 2025Article
- Assessment of the thoracic aorta after aortic root replacement and/or ascending aortic surgery using 3D relaxation-enhanced angiography without contrast and triggering.Frontiers in cardiovascular medicine · 2025Article
- Article
- Intelligent noninvasive meningioma grading with a fully automatic segmentation using interpretable multiparametric deep learning.European radiology · 2023Article
- Synthetic T2-weighted fat sat based on a generative adversarial network shows potential for scan time reduction in spine imaging in a multicenter test dataset.European radiology · 2023Article
- AI-based detection of contrast-enhancing MRI lesions in patients with multiple sclerosis.Insights into imaging · 2023Article
- Pediatric magnetic resonance angiography: to contrast or not to contrast.Pediatric radiology · 2023Review
- The feasibility of relaxation-enhanced angiography without contrast and triggering for preprocedural planning of transcatheter aortic valve implantation.Frontiers in cardiovascular medicine · 2023Article
- Imaging of the extracranial internal carotid artery in acute ischemic stroke: assessment of stenosis, plaques, and image quality using relaxation-enhanced angiography without contrast and triggering (REACT).Quantitative imaging in medicine and surgery · 2022Article
- Free-breathing non-contrast flow-independent cardiovascular magnetic resonance angiography using cardiac gated, magnetization-prepared 3D Dixon method: assessment of thoracic vasculature in congenital heart disease.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2021Article
- Contrast-free postoperative imaging of the pulmonary arteries: Intraindividual comparison of relaxation-enhanced angiography without contrast and triggering and time-resolved contrast-enhanced magnetic resonance angiography.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic ResonanceArticle
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate a novel flow-independent 3D isotropic REACT sequence compared with CE-MRA for the imaging of extracranial arteries in acute ischemic stroke (AIS).
methodsThis was a retrospective study of 35 patients who underwent a stroke protocol at 3 T including REACT (fixed scan time: 2:46 min) and CE-MRA of the extracranial arteries. Three radiologists evaluated scans regarding vessel delineation, signal, and contrast and assessed overall image noise and artifacts using 5-point scales (5: excellent delineation/no artifacts). Apparent signal- and contrast-to-noise ratios (aSNR/aCNR) were measured for the common carotid artery (CCA), internal carotid artery (ICA, C1 segment), and vertebral artery (V2 segment). Two radiologists graded the degree of proximal ICA stenosis.
resultsCompared to REACT, CE-MRA showed better delineation for the CCA and ICA (C1 and C2 segments) (median 5, range 2-5 vs. 4, range 3-5; P < 0.05). For the ICA (C1 and C2 segments), REACT provided a higher signal (5, range 3-5; P < 0.05/4.5, range 3-5; P > 0.05 vs. 4, range 2-5) and contrast (5, range 3-5 vs. 4, range 2-5; P > 0.05) than CE-MRA. The remaining segments of the blood-supplying vessels showed equal medians. There was no significant difference regarding artifacts, whereas REACT provided significantly lower image noise (4, range 3-5 vs. 4 range 2-5; P < 0.05) with a higher aSNR (P < 0.05) and aCNR (P < 0.05) for all vessels combined. For clinically relevant (≥50%) ICA stenosis, REACT achieved a detection sensitivity of 93.75% and a specificity of 100%.
conclusionGiven its fast acquisition, comparable image quality to CE-MRA and high sensitivity and specificity for the detection of ICA stenosis, REACT was proven to be a clinically applicable method to assess extracranial arteries in AIS.
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