Evidence map›Paper›PMID 33026491›Full record

ArticleJournal of neural transmission (Vienna, Austria : 1996)2020

Effects of agmatine, glutamate, arginine, and nitric oxide on executive functions in children with attention deficit hyperactivity disorder.

Seda Aybuke Sari, Dilara Ulger, Serpil Ersan, Deniz Bakir, Ayla Uzun Cicek, Firat Ismailoglu

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neural transmission (Vienna, Austria : 1996), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Increased Agmatine Degradation in Children with Specific Learning Disorder.International journal of molecular sciences · 2026
    Article
  5. Review
  6. Review
  7. Altered Arginine/Nitric Oxide Pathway in Children Diagnosed Attention Deficit Hyperactivity Disorder, and the Effect of 10 Weeks Methylphenidate Treatment.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Seda Aybuke SariDepartment of Child and Adolescent Psychiatry, Faculty of Medicine, Sivas Cumhuriyet University, Imaret Village, 58140, Sivas, Turkey. aybuke_sari@hotmail.com.ORCID 0000-0003-4793-0662
Dilara UlgerDepartment of Biochemistry, Faculty of Medicine, Sivas Cumhuriyet University, Sivas, Turkey.
Serpil ErsanDepartment of Biochemistry, Faculty of Medicine, Nigde Omer Halis University, Nigde, Turkey.
Deniz BakirDepartment of Biochemistry, Faculty of Medicine, Sivas Cumhuriyet University, Sivas, Turkey.
Ayla Uzun CicekDepartment of Child and Adolescent Psychiatry, Faculty of Medicine, Sivas Cumhuriyet University, Imaret Village, 58140, Sivas, Turkey.
Firat IsmailogluDepartment of Computer Engineering, Faculty of Engineering, Sivas Cumhuriyet University, Sivas, Turkey.
Sivas Cumhuriyet Üniversitesi · TRNiğde Ömer Halisdemir Üniversitesi · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we aimed to investigate the effects of agmatine, nitric oxide (NO), arginine, and glutamate, which are the metabolites in the polyamine pathway,  on the performance of executive functions (EF) in attention deficit hyperactivity disorder (ADHD). The ADHD group included 35 treatment-naive children (6-14 years old) who were ewly diagnosed with ADHD. The control group consisted of 35 healthy children with the same age and sex, having no previous psychiatric disorders. In the study groups, Stroop test (ST) and trail making test (TMT) were used to monitor EF, and blood samples were collected to measure agmatine with ultra-high-performance liquid chromatography and NO, glutamate, and arginine with enzyme-linked immunosorbent assay (ELISA). The EFs were significantly impaired in the ADHD group. The agmatine and arginine levels of the ADHD group were significantly higher than their peers. The NO and glutamate levels were also higher in the ADHD group compared to the control group, but these differences did not reach statistical significance. Children with ADHD had more difficulties during EF tasks compared to healthy children. The elevated NO and glutamate levels may be related with the impairment during EF tasks. Therefore, agmatine and arginine may increase to improve EF tasks through its inhibitory effect on the synthesis of NO and glutamate. Further studies are needed about polyamine pathway molecules to shed light on the pathophysiology of ADHD.

Indexed as

AgmatineAttention Deficit Disorder with HyperactivityArginineChildExecutive FunctionGlutamic AcidHumansNeuropsychological TestsNitric OxideAgmatineArginineGlutamic AcidNitric OxideAgmatineAttention deficit hyperactivity disorderExecutive functionsGlutamateNitric oxidePolyamine pathway

Identifiers

PMID33026491
OpenAlexW3091985420

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.